前列腺癌的分子磁共振成像

Molecular MR Imaging of Prostate Cancer.

作者信息

Kader Avan, Brangsch Julia, Kaufmann Jan O, Zhao Jing, Mangarova Dilyana B, Moeckel Jana, Adams Lisa C, Sack Ingolf, Taupitz Matthias, Hamm Bernd, Makowski Marcus R

机构信息

Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.

Department of Biology, Chemistry and Pharmacy, Institute of Biology, Freie Universität Berlin, Königin-Luise-Str. 1-3, 14195 Berlin, Germany.

出版信息

Biomedicines. 2020 Dec 22;9(1):1. doi: 10.3390/biomedicines9010001.

DOI:10.3390/biomedicines9010001

PMID:33375045

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7822017/

Abstract

This review summarizes recent developments regarding molecular imaging markers for magnetic resonance imaging (MRI) of prostate cancer (PCa). Currently, the clinical standard includes MR imaging using unspecific gadolinium-based contrast agents. Specific molecular probes for the diagnosis of PCa could improve the molecular characterization of the tumor in a non-invasive examination. Furthermore, molecular probes could enable targeted therapies to suppress tumor growth or reduce the tumor size.

摘要

本综述总结了前列腺癌（PCa）磁共振成像（MRI）分子成像标记物的最新进展。目前，临床标准包括使用非特异性钆基造影剂的磁共振成像。用于PCa诊断的特异性分子探针可以在非侵入性检查中改善肿瘤的分子特征。此外，分子探针可以实现靶向治疗，以抑制肿瘤生长或减小肿瘤大小。