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诺丁汉髋部骨折评分和临床虚弱量表作为短期和长期预后预测指标的性能:一项为期 3 年的髋部骨折患者双中心观察研究。

Performance of the Nottingham Hip Fracture Score and Clinical Frailty Scale as predictors of short and long-term outcomes: a dual-centre 3-year observational study of hip fracture patients.

机构信息

Western Sussex Hospitals NHS Foundation Trust, Worthing Hospital, Worthing, BN11 2DH, UK.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK.

出版信息

J Bone Miner Metab. 2021 May;39(3):494-500. doi: 10.1007/s00774-020-01187-x. Epub 2021 Jan 2.

Abstract

INTRODUCTION

Hip fractures account for a growing number of hospital admissions worldwide and are associated with significant morbidity and mortality. The Nottingham Hip Fracture Score (NHFS) was developed to help risk-stratify these patients. Frailty is increasingly recognised to be a predictor of adverse outcomes. The aim of this study, using prospectively collected data from two non-specialist UK hospitals, was to report contemporaneous outcomes for patients with a hip fracture and compare the performance of the NHFS with the Clinical Frailty Scale (CFS).

MATERIALS AND METHODS

Data were collected over a 3-year period (2016-2018) from patients admitted with a hip fracture. In-patient and 1-year mortality and length of stay were compared between the NHFS, CFS and other variables. For discrimination to predict mortality, area under the receiver operating characteristic (AUC) curves were produced.

RESULTS

2422 patients (70.6% female), median age 85 (interquartile range 78-90) were included, with 93% undergoing an operation. 30-day mortality was 5.8% and 1-year mortality 23.5%. Average hospital stay was 18.0 days (Standard deviation 13.7). For in-patient mortality AUC for NHFS was 0.69 (95% CI 0.64-0.74) and for CFS 0.63 (0.57-0.69); for 1-year mortality AUC for NHFS was 0.71 (0.68-0.73) and for CFS 0.67 (0.64-0.71). Neither score predicted extended hospital stay.

CONCLUSION

Both CFS and NHFS predict 1-year survival with similar, moderate discrimination. Future research could explore whether other factors could be combined to allow better risk stratification following a hip fracture to inform patients and clinicians.

摘要

简介

髋部骨折在全球范围内导致了越来越多的住院人数,并与显著的发病率和死亡率相关。诺丁汉髋部骨折评分(NHFS)的开发旨在帮助对这些患者进行风险分层。衰弱越来越被认为是不良预后的预测因素。本研究使用来自两家英国非专科医院的前瞻性收集数据,旨在报告髋部骨折患者的同期结果,并比较 NHFS 与临床虚弱评分(CFS)的性能。

材料和方法

数据是在 2016 年至 2018 年期间从因髋部骨折住院的患者中收集的。比较了 NHFS、CFS 和其他变量在住院和 1 年死亡率和住院时间方面的差异。为了预测死亡率,产生了接收者操作特征(ROC)曲线下的面积(AUC)。

结果

共纳入 2422 名患者(70.6%为女性),中位年龄为 85 岁(四分位距 78-90),93%接受了手术。30 天死亡率为 5.8%,1 年死亡率为 23.5%。平均住院时间为 18.0 天(标准差 13.7)。NHFS 用于住院死亡率的 AUC 为 0.69(95%CI 0.64-0.74),CFS 为 0.63(0.57-0.69);NHFS 用于 1 年死亡率的 AUC 为 0.71(0.68-0.73),CFS 为 0.67(0.64-0.71)。两种评分均不能预测延长的住院时间。

结论

CFS 和 NHFS 对 1 年生存率的预测具有相似的、中等的区分度。未来的研究可以探索是否可以结合其他因素来更好地对髋部骨折后进行风险分层,以便为患者和临床医生提供信息。

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