CARM1/PRMT4：超越转录共激活因子功能的新标记
CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator.
机构信息
Institut Curie - PSL Research University, Translational Research Department, Breast Cancer Biology Group, 75005 Paris, France.
Institut Curie - PSL Research University, Translational Research Department, Breast Cancer Biology Group, 75005 Paris, France.
出版信息
Trends Cell Biol. 2021 May;31(5):402-417. doi: 10.1016/j.tcb.2020.12.010. Epub 2021 Jan 20.
Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins. Beyond its well-established involvement in the regulation of transcription, the physiological functions of CARM1 are still poorly understood. However, recent studies have revealed novel roles of CARM1 in autophagy, metabolism, paraspeckles, and early development. In addition, CARM1 is emerging as an attractive therapeutic target and a drug response biomarker for certain types of cancer. Here, we provide a comprehensive overview of the structure of CARM1 and its post-translational modifications, its various functions, apart from transcriptional coactivation, and its involvement in cancer.
辅激活因子相关精氨酸甲基转移酶 1（CARM1）在 20 年前被鉴定为转录的核心调节剂，是一种催化蛋白质精氨酸甲基化的酶。除了其在转录调控中的明确作用外，CARM1 的生理功能仍知之甚少。然而，最近的研究揭示了 CARM1 在自噬、代谢、核周斑点和早期发育中的新作用。此外，CARM1 作为某些类型癌症的有吸引力的治疗靶点和药物反应生物标志物正在出现。在这里，我们提供了 CARM1 的结构及其翻译后修饰、除转录共激活以外的各种功能以及其在癌症中的作用的全面概述。
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