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特应性皮炎患者的[具体内容缺失,无法准确翻译]定植:揭示未知的尝试。

Colonization With in Atopic Dermatitis Patients: Attempts to Reveal the Unknown.

作者信息

Ogonowska Patrycja, Gilaberte Yolanda, Barańska-Rybak Wioletta, Nakonieczna Joanna

机构信息

Laboratory of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.

Department of Dermatology, University Hospital Miguel Servet, Zaragoza, Spain.

出版信息

Front Microbiol. 2021 Jan 11;11:567090. doi: 10.3389/fmicb.2020.567090. eCollection 2020.

Abstract

Atopic dermatitis (AD) patients are massively colonized with () in lesional and non-lesional skin. A skin infection may become systemic if left untreated. Of interest, the incidence of multi-drug resistant (MRSA) in AD patients is higher as compared to a healthy population, which makes treatment even more challenging. Information on the specific genetic background of accompanying and/or causing AD flares would be of great importance in terms of possible treatment option development. In this review, we summarized the data on the prevalence of in general in AD skin, and the prevalence of specific clones that might be associated with flares of eczema. We put our special interest in the presence and role of staphylococcal enterotoxins as important virulence factors in the epidemiology of AD-derived . Also, we summarize the present and potentially useful future anti-staphylococcal treatment.

摘要

特应性皮炎(AD)患者的皮损和非皮损皮肤中大量定植有()。皮肤感染若不治疗可能会发展为全身性感染。有趣的是,与健康人群相比,AD患者中耐多药(MRSA)的发生率更高,这使得治疗更具挑战性。关于伴随和/或引发AD发作的()的特定遗传背景信息,对于可能的治疗方案开发具有重要意义。在本综述中,我们总结了AD皮肤中()的总体流行数据,以及可能与湿疹发作相关的特定克隆的流行情况。我们特别关注葡萄球菌肠毒素作为AD衍生()流行病学中重要毒力因子的存在和作用。此外,我们总结了目前以及未来可能有用的抗葡萄球菌治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05f6/7830525/4f6cb166ebac/fmicb-11-567090-g001.jpg

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