使用N-芳基三氟乙酰亚胺酰氯和苯衍生物进行Friedel-Crafts合成双（三氟甲基化）-4-芳基-3,4-二氢喹唑啉、双（三氟甲基化）-3,4-二氢喹唑啉-4-醇和三氟甲基芳基酮亚胺。
Friedel-Crafts synthesis of bis(trifluoromethylated)-4-aryl-3,4-dihydroquinazolines, bis(trifluoromethylated)-3,4-dihydroquinazoline-4-ols and trifluoromethyl arylketoimines using N-aryltrifluoroacetimidoyl chlorides and benzene derivatives.
作者信息
Kazemi Elham, Darehkordi Ali, Abbasi Alireza
机构信息
Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanja, Rafsanjan, 77176, Iran.
School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
出版信息
Mol Divers. 2022 Apr;26(2):815-825. doi: 10.1007/s11030-021-10189-4. Epub 2021 Feb 3.
A simple and straightforward approach to access biologically important N-heterocycles, namely bis(trifluoromethylated)-4-aryl-3,4-dihydroquinazolines, bis(trifluoromethylated)-3,4-dihydroquinazoline-4-ols and trifluoromethyl arylketoimines, as a group of important frameworks or initial substance from N-aryltrifluoroacetimidoyl chlorides with benzene derivatives via Friedel-Crafts reaction has been described. This novel strategy provides synthesis of trifluoromethylated dihydroquinazolines and trifluoromethyl arylketoimines in good to excellent yields.
已描述了一种简单直接的方法，通过傅克反应从N-芳基三氟乙酰亚胺酰氯与苯衍生物中获取具有生物学重要性的氮杂环化合物，即双（三氟甲基化）-4-芳基-3,4-二氢喹唑啉、双（三氟甲基化）-3,4-二氢喹唑啉-4-醇和三氟甲基芳基酮亚胺，它们是一组重要的骨架或起始物质。这种新策略能够以良好至优异的产率合成三氟甲基化二氢喹唑啉和三氟甲基芳基酮亚胺。
Zotero 插件