烯丙基砜盐和磺酰基保护的β-氨基酮与环氧化合物融合的 2-亚甲基吡咯烷和 S 含吡咯的反应。
The reaction of prop-2-ynylsulfonium salts and sulfonyl-protected β-amino ketones to epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles.
机构信息
School of Medicine, Zhejiang University City College, Hangzhou, 310015, P. R. China.
出版信息
Chem Commun (Camb). 2021 Mar 14;57(21):2657-2660. doi: 10.1039/d0cc07745c. Epub 2021 Feb 15.
PMID:33587730
Abstract
A novel divergent domino annulation reaction of prop-2-ynylsulfonium salts with sulfonyl-protected β-amino ketones has been developed, affording various epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles in moderate to excellent yields. Prop-2-ynylsulfonium salts act as C synthons in the reactions providing a promising epoxide-fused skeleton in a single operation with readily accessible starting materials.
摘要
一种新颖的丙炔基砜盐与磺酰基保护的β-氨基酮的发散多米诺环加成反应已经被开发出来，以中等至优异的产率得到了各种环氧化合物融合的 2-亚甲基吡咯烷和含 S 的吡咯。丙炔基砜盐在反应中充当 C 合成子，提供了一个有前途的环氧融合骨架，在单一操作中使用了易于获得的起始原料。
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