果蝇生殖干细胞维持和分化的表观遗传调控。
Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.
机构信息
Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Baltimore, MD, 21218, USA.
Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Baltimore, MD, 21218, USA.
出版信息
Dev Biol. 2021 May;473:105-118. doi: 10.1016/j.ydbio.2021.02.003. Epub 2021 Feb 18.
Gametogenesis is one of the most extreme cellular differentiation processes that takes place in Drosophila male and female germlines. This process begins at the germline stem cell, which undergoes asymmetric cell division (ACD) to produce a self-renewed daughter that preserves its stemness and a differentiating daughter cell that undergoes epigenetic and genomic changes to eventually produce haploid gametes. Research in molecular genetics and cellular biology are beginning to take advantage of the continually advancing genomic tools to understand: (1) how germ cells are able to maintain their identity throughout the adult reproductive lifetime, and (2) undergo differentiation in a balanced manner. In this review, we focus on the epigenetic mechanisms that address these two questions through their regulation of germline-soma communication to ensure germline stem cell identity and activity.
配子发生是在果蝇雌雄生殖系中发生的最极端的细胞分化过程之一。这个过程从生殖干细胞开始，它经历不对称细胞分裂（ACD）产生一个自我更新的女儿细胞，保留其干细胞特性，和一个经历表观遗传和基因组变化的分化子细胞，最终产生单倍体配子。分子遗传学和细胞生物学的研究开始利用不断发展的基因组工具来理解：（1）生殖细胞如何在整个成年生殖寿命中保持其身份，以及（2）以平衡的方式进行分化。在这篇综述中，我们专注于通过调节生殖系-体通讯来解决这两个问题的表观遗传机制，以确保生殖干细胞的身份和活性。
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