生存分析 - 第2部分：Cox比例风险模型。
Survival analysis-part 2: Cox proportional hazards model.
作者信息
Deo Salil Vasudeo, Deo Vaishali, Sundaram Varun
机构信息
Louis Stokes Veteran Affairs Medical Center, Cleveland, OH USA.
Case Western Reserve University School of Medicine, Cleveland, OH USA.
出版信息
Indian J Thorac Cardiovasc Surg. 2021 Mar;37(2):229-233. doi: 10.1007/s12055-020-01108-7. Epub 2021 Jan 2.
Abstract
UNLABELLED
Learning objectives: 1. To understand the log-rank test and limitations of the log-rank test in comparing survival between groups. 2. To understand the fundamental concepts of the proportional hazards assumption. 3. To understand basic steps in the development of the Cox proportional hazards model and reported hazard ratios. 4. To understand how results of a Cox model run using STATA© (a commonly used proprietary statistical software) can be understood and interpreted.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s12055-020-01108-7.
摘要
未标注
学习目标：1. 理解对数秩检验以及对数秩检验在比较组间生存情况时的局限性。2. 理解比例风险假设的基本概念。3. 理解Cox比例风险模型构建的基本步骤以及报告的风险比。4. 理解如何理解和解释使用STATA©（一种常用的专有统计软件）运行Cox模型的结果。
补充信息
在线版本包含可在10.1007/s12055-020-01108-7获取的补充材料。
相似文献
1
Survival analysis-part 2: Cox proportional hazards model.
Indian J Thorac Cardiovasc Surg. 2021 Mar;37(2):229-233. doi: 10.1007/s12055-020-01108-7. Epub 2021 Jan 2.
2
Model-free estimates that complement information obtained from the hazard ratio.
Indian J Thorac Cardiovasc Surg. 2021 Jul;37(4):480-484. doi: 10.1007/s12055-021-01167-4. Epub 2021 Apr 5.
3
Quantifying treatment differences in confirmatory trials under non-proportional hazards.
J Appl Stat. 2020 Sep 3;49(2):466-484. doi: 10.1080/02664763.2020.1815673. eCollection 2022.
4
Sequential tests for non-proportional hazards data.
Lifetime Data Anal. 2017 Jul;23(3):339-352. doi: 10.1007/s10985-016-9360-5. Epub 2016 Mar 11.
5
Survival analysis: part II - applied clinical data analysis.
Korean J Anesthesiol. 2019 Oct;72(5):441-457. doi: 10.4097/kja.19183. Epub 2019 May 17.
6
Testing the proportional hazards assumption in cox regression and dealing with possible non-proportionality in total joint arthroplasty research: methodological perspectives and review.
BMC Musculoskelet Disord. 2021 May 28;22(1):489. doi: 10.1186/s12891-021-04379-2.
7
Methods for non-proportional hazards in clinical trials: A systematic review.
Stat Methods Med Res. 2024 Jun;33(6):1069-1092. doi: 10.1177/09622802241242325. Epub 2024 Apr 9.
8
Survival outcome prediction in cervical cancer: Cox models vs deep-learning model.
Am J Obstet Gynecol. 2019 Apr;220(4):381.e1-381.e14. doi: 10.1016/j.ajog.2018.12.030. Epub 2018 Dec 21.
9
Application of random survival forests in understanding the determinants of under-five child mortality in Uganda in the presence of covariates that satisfy the proportional and non-proportional hazards assumption.
BMC Res Notes. 2017 Sep 7;10(1):459. doi: 10.1186/s13104-017-2775-6.
10
Survival time prediction by integrating cox proportional hazards network and distribution function network.
BMC Bioinformatics. 2021 Apr 15;22(1):192. doi: 10.1186/s12859-021-04103-w.
引用本文的文献
1
Evaluation of Machine Learning and Traditional Statistical Models to Assess the Value of Stroke Genetic Liability for Prediction of Risk of Stroke Within the UK Biobank.
Healthcare (Basel). 2025 Apr 26;13(9):1003. doi: 10.3390/healthcare13091003.
2
Frailty modelling for multidrug-resistant tuberculosis mortality in Namibia.
J Public Health Res. 2025 May 11;14(2):22799036251336969. doi: 10.1177/22799036251336969. eCollection 2025 Apr.
3
Development of a Predictive Model for Metabolic Syndrome Using Noninvasive Data and its Cardiovascular Disease Risk Assessments: Multicohort Validation Study.
J Med Internet Res. 2025 May 2;27:e67525. doi: 10.2196/67525.
4
Economic Evaluation of Penpulimab Plus Paclitaxel and Carboplatin Combination Therapy as First-Line Treatment for Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer in China.
Clin Drug Investig. 2025 May;45(5):283-294. doi: 10.1007/s40261-025-01439-6. Epub 2025 Apr 21.
5
Explainable transformer-based deep survival analysis in childhood acute lymphoblastic leukemia.
Comput Biol Med. 2025 Jun;191:110118. doi: 10.1016/j.compbiomed.2025.110118. Epub 2025 Apr 7.
6
Machine Learning to Assist in Managing Acute Kidney Injury in General Wards: Multicenter Retrospective Study.
J Med Internet Res. 2025 Mar 18;27:e66568. doi: 10.2196/66568.
7
Glucagon-like peptide-1 receptor agonists improve metabolic dysfunction-associated steatotic liver disease outcomes.
Sci Rep. 2025 Feb 10;15(1):4947. doi: 10.1038/s41598-025-89408-z.
8
A robust ensemble feature selection approach to prioritize genes associated with survival outcome in high-dimensional gene expression data.
Front Syst Biol. 2024;4. doi: 10.3389/fsysb.2024.1355595. Epub 2024 Mar 20.
9
Association of pre- and post-diagnosis dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) with overall survival in patients with ovarian cancer: a prospective cohort study.
J Transl Med. 2025 Jan 30;23(1):134. doi: 10.1186/s12967-024-06041-6.
10
AI-assisted exposure-response data analysis: Quantifying heterogeneous causal effects of exposures on survival times.
Glob Epidemiol. 2024 Dec 25;9:100179. doi: 10.1016/j.gloepi.2024.100179. eCollection 2025 Jun.
本文引用的文献
1
Nonproportional Hazards for Time-to-Event Outcomes in Clinical Trials: JACC Review Topic of the Week.
J Am Coll Cardiol. 2019 Oct 22;74(16):2102-2112. doi: 10.1016/j.jacc.2019.08.1034.
2
Survival Analysis and Interpretation of Time-to-Event Data: The Tortoise and the Hare.
Anesth Analg. 2018 Sep;127(3):792-798. doi: 10.1213/ANE.0000000000003653.
3
Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy.
N Engl J Med. 2016 Apr 21;374(16):1511-20. doi: 10.1056/NEJMoa1602001. Epub 2016 Apr 3.
4
Time-to-Event Analysis.
JAMA. 2016 Mar 8;315(10):1046-7. doi: 10.1001/jama.2016.1825.
5
The simplest statistical test: how to check for a difference between treatments.
BMJ. 2006 May 27;332(7552):1256-8. doi: 10.1136/bmj.332.7552.1256.
6
The logrank test.
BMJ. 2004 May 1;328(7447):1073. doi: 10.1136/bmj.328.7447.1073.
7
Proportional hazards (Cox) regression.
J Gen Intern Med. 1993 Dec;8(12):702-11. doi: 10.1007/BF02598295.
Zotero 插件