越南胡志明市甲状腺癌发病趋势及组织学模式（1996-2015 年）：一项基于人群的研究。
Trends in incidence and histological pattern of thyroid cancer in Ho Chi Minh City, Vietnam (1996-2015): a population-based study.
机构信息
Ho Chi Minh City Oncology Hospital, Ho Chi Minh City, Vietnam.
Department of Oncology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
出版信息
BMC Cancer. 2021 Mar 20;21(1):296. doi: 10.1186/s12885-021-08023-z.
BACKGROUND
The burden and trend of thyroid cancer in Vietnam have not been well documented. This study aimed to investigate the trends in incidence and histological pattern of thyroid cancer in Ho Chi Minh City from 1996 to 2015.
METHODS
A population-based study retrieved data from the Ho Chi Minh City Cancer Registry during 1996-2015. Trends in the incidence of thyroid cancer were investigated based on age, gender, and histology for each 5-year period. Annual percentage change (APC) in incidence rates was estimated using Joinpoint regression analysis.
RESULTS
In the study period, there were 5953 thyroid cancer cases (men-to-women ratio 1:4.5) newly diagnosed in Ho Chi Minh City with the mean age of 42.9 years (±14.9 years). The age-standardized incidence rate of thyroid cancer increased from 2.4 per 100,000 during 1996-2000 (95% confidence interval [95% CI]: 2.2-2.6) to 7.5 per 100,000 during 2011-2015 (95% CI: 7.3-7.9), corresponded to an overall APC of 8.7 (95% CI 7.6-9.9). The APC in men and women was 6.2 (95% CI: 4.2-8.2) and 9.2 (95% CI: 8.0-10.4), respectively. The incidence rate in the < 45 years age group was the highest diagnosed overall and increased significantly in both men (APC 11.0) and women (APC 10.1). Both genders shared similar distribution of subtype incidences, with papillary thyroid cancer constituted the most diagnosed (73.3% in men and 85.2% in women). The papillary thyroid cancer observed a markedly increase overall (APC of 10.7 (95% CI 9.3-12.0)).
CONCLUSIONS
There were appreciable increases in the age-standardized incidence rate of thyroid cancer in both genders, mainly contributed by the papillary subtype. The age of patients at diagnosis decreased gradually. The widespread utilization of advanced diagnostic techniques and healthcare accessibility improvement might play a potential role in these trends. Further investigations are needed to comprehend the risk factors and trends fully.
背景
越南的甲状腺癌负担和趋势尚未得到很好的记录。本研究旨在调查胡志明市 1996 年至 2015 年期间甲状腺癌的发病率和组织学模式趋势。
方法
本基于人群的研究从 1996 年至 2015 年期间检索了胡志明市癌症登记处的数据。根据每个 5 年期间的年龄、性别和组织学，调查了甲状腺癌发病率的趋势。使用 Joinpoint 回归分析估计发病率的年变化百分比（APC）。
结果
在研究期间，胡志明市共诊断出 5953 例新的甲状腺癌病例（男女比例为 1:4.5），平均年龄为 42.9±14.9 岁。甲状腺癌的年龄标准化发病率从 1996 年至 2000 年的每 100,000 人 2.4 例（95%置信区间 [95%CI]：2.2-2.6）增加到 2011 年至 2015 年的每 100,000 人 7.5 例（95%CI：7.3-7.9），总体 APC 为 8.7（95%CI 7.6-9.9）。男性和女性的 APC 分别为 6.2（95%CI：4.2-8.2）和 9.2（95%CI：8.0-10.4）。<45 岁年龄组的诊断率最高，男性（APC11.0）和女性（APC10.1）均显著增加。两种性别均具有相似的亚型发病率分布，其中乳头状甲状腺癌是最常见的诊断类型（男性占 73.3%，女性占 85.2%）。总体上，乳头状甲状腺癌显著增加（APC 为 10.7（95%CI 9.3-12.0））。
结论
男女甲状腺癌的年龄标准化发病率均有显著增加，主要由乳头状亚型引起。患者的诊断年龄逐渐下降。先进诊断技术的广泛应用和医疗保健可及性的提高可能在这些趋势中发挥了潜在作用。需要进一步研究以充分了解风险因素和趋势。
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