可扩展的全合成、去甲木沙海绵素 B 的 IP3R 抑制活性，以及对线粒体功能和癌细胞存活的影响。
Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival.
机构信息
Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.
Center for Integrative Biology, Faculty of Sciences, Geroscience Center for Brain Health and Metabolism, Universidad Mayor, Santiago, Chile.
出版信息
Angew Chem Int Ed Engl. 2021 May 10;60(20):11278-11282. doi: 10.1002/anie.202102259. Epub 2021 Apr 8.
Abstract
The scalable synthesis of the oxaquinolizidine marine natural product desmethylxestospongin B is based on the early application of Ireland-Claisen rearrangement, macrolactamization, and a late-stage installation of the oxaquinolizidine units by lactam reduction. The synthesis serves as the source of material to investigate calcium signaling and its effect on mitochondrial metabolism in various cell types, including cancer cells.
摘要
可扩展合成海洋天然产物去甲氧基西沙定 B 的关键步骤包括：早期应用 Ireland-Claisen 重排、大环内酯化，以及晚期通过内酰胺还原引入氧杂喹啉啶单元。该合成路线为研究钙信号及其对各种细胞类型（包括癌细胞）中线粒体代谢的影响提供了物质来源。
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