Saa3（血清淀粉样蛋白 A3）、炎症和胆固醇代谢之间的性别二态关系调节小鼠的动脉粥样硬化。
Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice.
机构信息
Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition (A.C., S.W., L.G., D.G., K.E.T., J.T., C.S., K.B.R., C.T., T.V., L.J.D.H.), University of Washington, Seattle.
Diabetes Institute (A.C., S.W., L.G., D.G., K.E.T., T.W., J.T., C.S., K.D.O., K.B.R., C.T., T.V., L.J.D.H.), University of Washington, Seattle.
出版信息
Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e299-e313. doi: 10.1161/ATVBAHA.121.316066. Epub 2021 Mar 25.
Abstract
[Figure: see text].
摘要
[图：见正文]。
相似文献
1
Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice.
Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e299-e313. doi: 10.1161/ATVBAHA.121.316066. Epub 2021 Mar 25.
2
Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report.
Arterioscler Thromb Vasc Biol. 2024 Jul;44(7):1646-1657. doi: 10.1161/ATVBAHA.124.320797. Epub 2024 May 2.
3
Haloperidol inhibits the development of atherosclerotic lesions in LDL receptor knockout mice.
Br J Pharmacol. 2015 May;172(9):2397-405. doi: 10.1111/bph.13067. Epub 2015 Mar 16.
4
Krüppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development.
Cardiovasc Res. 2022 Jan 29;118(2):475-488. doi: 10.1093/cvr/cvab027.
5
A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis.
Circ Res. 2019 Jan 4;124(1):94-100. doi: 10.1161/CIRCRESAHA.118.313234.
6
Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages.
Circulation. 2018 Oct 23;138(17):1850-1863. doi: 10.1161/CIRCULATIONAHA.117.031702.
7
CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.
Circ Res. 2021 Jul 9;129(2):280-295. doi: 10.1161/CIRCRESAHA.119.316062. Epub 2021 May 12.
8
Serum amyloid A3 is pro-atherogenic.
Atherosclerosis. 2018 Jan;268:32-35. doi: 10.1016/j.atherosclerosis.2017.11.011. Epub 2017 Nov 17.
9
Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y2 in Mice.
Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1577-86. doi: 10.1161/ATVBAHA.115.307397. Epub 2016 Jun 23.
10
CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway.
Cell Death Dis. 2021 Mar 10;12(3):254. doi: 10.1038/s41419-021-03544-8.
引用本文的文献
1
The various roles of TREM2 in cardiovascular disease.
Front Immunol. 2025 Feb 27;16:1462508. doi: 10.3389/fimmu.2025.1462508. eCollection 2025.
2
SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model.
Cell Death Discov. 2025 Jan 26;11(1):25. doi: 10.1038/s41420-025-02299-x.
3
Effect of Seminal Plasma on the Freezability of Boar Sperm.
Animals (Basel). 2024 Dec 18;14(24):3656. doi: 10.3390/ani14243656.
4
Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases.
Geroscience. 2025 Feb;47(1):301-337. doi: 10.1007/s11357-024-01489-2. Epub 2025 Jan 3.
5
Exacerbation of atherosclerosis, hyperlipidemia and inflammation by MK886, an inhibitor of leukotriene biosynthesis, in obese and diabetic mice.
Curr Res Pharmacol Drug Discov. 2024 Oct 10;7:100203. doi: 10.1016/j.crphar.2024.100203. eCollection 2024.
6
Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex.
Am J Physiol Cell Physiol. 2024 Dec 1;327(6):C1514-C1531. doi: 10.1152/ajpcell.00647.2024. Epub 2024 Oct 28.
7
Effects of low-frequency ultrasound combined with anti-MRSA agents on the mouse model of pulmonary infection.
Microbiol Spectr. 2024 Feb 7;12(3):e0101623. doi: 10.1128/spectrum.01016-23.
8
Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice.
Sci Rep. 2023 Nov 5;13(1):19123. doi: 10.1038/s41598-023-46304-8.
9
Amyloid β induces cardiac dysfunction and neuro-signaling impairment in the heart of an Alzheimer's disease model.
bioRxiv. 2023 Jul 11:2023.07.11.548558. doi: 10.1101/2023.07.11.548558.
10
Serum amyloid A and metabolic disease: evidence for a critical role in chronic inflammatory conditions.
Front Cardiovasc Med. 2023 Jun 15;10:1197432. doi: 10.3389/fcvm.2023.1197432. eCollection 2023.
本文引用的文献
1
Testosterone stimulates cholesterol clearance from human macrophages by activating LXRα.
Life Sci. 2021 Mar 15;269:119040. doi: 10.1016/j.lfs.2021.119040. Epub 2021 Jan 13.
2
Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung.
Front Immunol. 2020 Aug 7;11:1698. doi: 10.3389/fimmu.2020.01698. eCollection 2020.
3
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
Circ Res. 2020 Jul 17;127(3):402-426. doi: 10.1161/CIRCRESAHA.120.316903. Epub 2020 Jul 16.
4
Presence of serum amyloid A3 in mouse plasma is dependent on the nature and extent of the inflammatory stimulus.
Sci Rep. 2020 Jun 25;10(1):10397. doi: 10.1038/s41598-020-66898-7.
5
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.
Immunity. 2020 Jun 16;52(6):1057-1074.e7. doi: 10.1016/j.immuni.2020.04.001. Epub 2020 May 1.
6
Macrophage subsets in atherosclerosis as defined by single-cell technologies.
J Pathol. 2020 Apr;250(5):705-714. doi: 10.1002/path.5392. Epub 2020 Mar 11.
7
Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2.
Biochem Biophys Res Commun. 2020 Mar 19;523(4):1027-1033. doi: 10.1016/j.bbrc.2020.01.045. Epub 2020 Jan 20.
8
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Neuron. 2020 Mar 4;105(5):837-854.e9. doi: 10.1016/j.neuron.2019.12.007. Epub 2020 Jan 2.
9
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.
Nature. 2019 Nov;575(7783):512-518. doi: 10.1038/s41586-019-1631-3. Epub 2019 Oct 9.
10
Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.
N Engl J Med. 2019 Feb 21;380(8):752-762. doi: 10.1056/NEJMoa1809798. Epub 2018 Nov 10.
Zotero 插件