血清维生素 D 浓度低与肥胖而非瘦型非酒精性脂肪性肝病相关：一项横断面研究。
Low serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study.
机构信息
Department of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
出版信息
Nutr J. 2021 Apr 1;20(1):30. doi: 10.1186/s12937-021-00690-9.
BACKGROUND
A low serum vitamin D concentration has been reported to be associated with an increased risk of non-alcoholic fatty liver disease (NAFLD); however, whether lean or obese individuals show a similar association between vitamin D and NAFLD remains speculative. This study aimed to explore the relationship between serum vitamin D concentration and NAFLD in lean and obese Chinese adults.
METHODS
This cross-sectional study included 2538 participants (1360 men and 1178 women) who underwent health checkups at the First Affiliated Hospital, Zhejiang University School of Medicine in 2019. NAFLD was diagnosed by liver ultrasound excluding other causes. The association of serum vitamin D concentration with NAFLD was analyzed in lean and obese participants.
RESULTS
The overall prevalence of NAFLD was 33.61% (13.10% in lean and 53.32% in obese) in this study population. The serum vitamin D levels of obese NAFLD patients were lower than those of obese NAFLD-free controls. However, the serum vitamin D levels of lean NAFLD patients were comparable to those of lean NAFLD-free controls. Serum vitamin D level was negatively correlated with the prevalence of NAFLD in obese but not lean participants. Serum vitamin D level was independently associated with the risk of NAFLD in obese participants, with an adjusted odds ratio (95% CI) of 0.987 (0.981-0.993). However, serum vitamin D level was not related to the risk of NAFLD in lean participants.
CONCLUSIONS
A low serum vitamin D level is associated with NAFLD in obese but not lean participants.
背景
有报道称血清维生素 D 浓度低与非酒精性脂肪性肝病（NAFLD）风险增加有关；然而，瘦或肥胖个体的维生素 D 与 NAFLD 之间是否存在类似的关联仍存在推测。本研究旨在探讨血清维生素 D 浓度与中国瘦和肥胖成年人 NAFLD 之间的关系。
方法
本横断面研究纳入了 2019 年在浙江大学医学院附属第一医院进行健康检查的 2538 名参与者（男 1360 名，女 1178 名）。NAFLD 通过排除其他原因的肝脏超声诊断。分析了瘦和肥胖参与者血清维生素 D 浓度与 NAFLD 的关系。
结果
在该研究人群中，NAFLD 的总体患病率为 33.61%（瘦组为 13.10%，肥胖组为 53.32%）。肥胖 NAFLD 患者的血清维生素 D 水平低于肥胖非 NAFLD 对照组。然而，瘦 NAFLD 患者的血清维生素 D 水平与瘦非 NAFLD 对照组相当。血清维生素 D 水平与肥胖参与者的 NAFLD 患病率呈负相关，但与瘦参与者的 NAFLD 患病率无关。血清维生素 D 水平与肥胖参与者的 NAFLD 风险独立相关，调整后的优势比（95%CI）为 0.987（0.981-0.993）。然而，血清维生素 D 水平与瘦参与者的 NAFLD 风险无关。
结论
血清维生素 D 水平低与肥胖参与者的 NAFLD 相关，但与瘦参与者的 NAFLD 无关。
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