脂肪源性干细胞外泌体通过介导肌腱源性干细胞促进肩袖修复。
Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells.
机构信息
Department of Joint Surgery, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai, 200120, PR China.
Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, Tongji University, Shanghai, 200120, PR China.
出版信息
Regen Med. 2021 Apr;16(4):359-372. doi: 10.2217/rme-2021-0004. Epub 2021 Apr 19.
To evaluate the potential capability of adipose-derived stem cell exosomes (ADSC-exos) on rotator cuff repair by mediating the tendon-derived stem cells (TDSCs) and explored the mechanism. First, we investigated the growth, survival and migration of TDSCs in the presence of ADSC-exos . Using a rat rotator cuff injury model to analyze the ability of the ADSC-exos to promote rotator cuff healing . The hydrogel with ADSC-exos significantly improved the osteogenic and adipogenesis differentiation and enhanced the expression of , , , and and the mechanical properties of the articular portion. The ADSC-exos have the potential to promote the rotator cuff repair by mediating the TDSCs.
为了评估脂肪来源干细胞外泌体（ADSC-exos）通过介导肌腱来源干细胞（TDSCs）在肩袖修复中的潜在能力，并探讨其机制。首先，我们研究了 ADSC-exos 存在下 TDSCs 的生长、存活和迁移。利用大鼠肩袖损伤模型分析 ADSC-exos 促进肩袖愈合的能力。含有 ADSC-exos 的水凝胶显著改善了成骨和成脂分化，并增强了 、 、 、 和 的表达，以及关节部分的机械性能。ADSC-exos 有可能通过介导 TDSCs 促进肩袖修复。
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