风湿性疾病中的脂质代谢谱
Lipid Metabolism Profiles in Rheumatic Diseases.
作者信息
Chen Weilin, Wang Qi, Zhou Bin, Zhang Lihua, Zhu Honglin
机构信息
Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.
出版信息
Front Pharmacol. 2021 Apr 9;12:643520. doi: 10.3389/fphar.2021.643520. eCollection 2021.
Abstract
Rheumatic diseases are a group of chronic autoimmune disorders that involve multiple organs or systems and have high mortality. The mechanisms of these diseases are still ill-defined, and targeted therapeutic strategies are still challenging for physicians. Recent research indicates that cell metabolism plays important roles in the pathogenesis of rheumatic diseases. In this review, we mainly focus on lipid metabolism profiles (dyslipidaemia, fatty acid metabolism) and mechanisms in rheumatic diseases and discuss potential clinical applications based on lipid metabolism profiles.
摘要
风湿性疾病是一组慢性自身免疫性疾病，累及多个器官或系统，死亡率高。这些疾病的发病机制仍不明确，针对这些疾病的治疗策略对医生来说仍然具有挑战性。最近的研究表明，细胞代谢在风湿性疾病的发病机制中起重要作用。在这篇综述中，我们主要关注风湿性疾病中的脂质代谢概况（血脂异常、脂肪酸代谢）及其机制，并基于脂质代谢概况讨论潜在的临床应用。
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