《药物使用者中实施 PrEP 的过去、现在和未来》。
The Past, Present, and Future of PrEP implementation Among People Who Use Drugs.
机构信息
Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA.
Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
出版信息
Curr HIV/AIDS Rep. 2021 Aug;18(4):328-338. doi: 10.1007/s11904-021-00556-z. Epub 2021 Apr 27.
Abstract
PURPOSE OF REVIEW
Recent HIV outbreaks among people who use drugs (PWUD) necessitate additional HIV prevention tools. Pre-exposure prophylaxis (PrEP) is highly efficacious yet uptake among PWUD remains exceedingly low. To address multilevel, complex barriers to PrEP use among PWUD, a range of intervention strategies are needed.
RECENT FINDINGS
The literature on interventions to optimize PrEP use among PWUD is nascent, comprising small pilots and demonstration projects in early phases of intervention development. Initial studies suggest that structural, healthcare, interpersonal, and individual-level interventions can improve PrEP use for PWUD, and a number of efficacy trials are underway. Future studies are needed to optimize the use of new PrEP modalities (e.g., injectable PrEP), simultaneously target multilevel challenges to PrEP use, and evaluate the integration of PrEP into other service settings and substance use treatment modalities.
摘要
目的综述： 近期吸毒人群（PWUD）中的艾滋病毒爆发，需要额外的艾滋病毒预防工具。暴露前预防（PrEP）非常有效，但 PWUD 的使用率仍然极低。为了解决 PWUD 使用 PrEP 时存在的多层次、复杂的障碍，需要采取一系列干预策略。
最新发现： 关于优化 PWUD 使用 PrEP 的干预措施的文献还处于起步阶段，主要是干预措施发展早期的小型试点和示范项目。初步研究表明，结构、医疗保健、人际和个人层面的干预措施可以提高 PWUD 使用 PrEP 的效果，目前正在进行多项疗效试验。未来的研究需要优化新的 PrEP 模式（如注射 PrEP）的使用，同时针对 PrEP 使用的多层次挑战，并评估将 PrEP 纳入其他服务环境和物质使用治疗模式。
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