载脂蛋白 Eɛ2/ɛ4 基因型与非裔美国人阿尔茨海默病和轻度认知障碍的关联。
Association Between the APOEɛ2/ɛ4 Genotype and Alzheimer's Disease and Mild Cognitive Impairment Among African Americans.
机构信息
University of Pittsburgh, School of Nursing, Pittsburgh, PA, USA.
University of Pittsburgh, Department of Biostatistics, Pittsburgh, PA, USA.
出版信息
J Alzheimers Dis. 2021;81(3):943-948. doi: 10.3233/JAD-201613.
We examined the association between APOEɛ2/ɛ4 with incident Alzheimer's disease (AD) and mild cognitive impairment (MCI) among African Americans using the national dataset from the National Alzheimer's Coordinating Center (NACC) from 2005 to September 2019. Compared to ɛ3/ɛ3 carriers, ɛ2/ɛ4 carriers exhibited a similar risk of incident AD (adjusted hazard ratio [aHR] = 0.85, 95% CI [0.39, 1.84]) among the AD cohort and similar risk of incident MCI (aHR = 0.88, 95% CI [0.51, 1.50]) among the MCI cohort. Our findings suggest that, unlike the increased risk of AD and MCI in non-Latino whites, APOEɛ2/ɛ4 genotype is not associated with the incidence of AD and MCI among African Americans.
我们使用 2005 年至 2019 年 9 月期间美国国家阿尔茨海默病协调中心（NACC）的全国性数据集，研究了载脂蛋白 Eɛ2/ɛ4 与非裔美国人阿尔茨海默病（AD）和轻度认知障碍（MCI）发病之间的关联。与携带 ɛ3/ɛ3 基因型的个体相比，AD 队列中携带 ɛ2/ɛ4 基因型的个体发病 AD 的风险相似（校正后的危险比[aHR] = 0.85，95%CI [0.39, 1.84]），MCI 队列中发病 MCI 的风险也相似（aHR = 0.88，95%CI [0.51, 1.50]）。我们的研究结果表明，与非拉丁裔白种人 APOEɛ2/ɛ4 基因型增加 AD 和 MCI 发病风险不同，APOEɛ2/ɛ4 基因型与非裔美国人 AD 和 MCI 的发病无关。
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