Suppr超能文献

酶名称“罗得西亚蛋白酶”是否应停用?

Should the enzyme name 'rhodesain' be discontinued?

作者信息

Steverding Dietmar, Caffrey Conor R

机构信息

Bob Champion Research and Education Centre, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.

Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.

出版信息

Mol Biochem Parasitol. 2021 Sep;245:111395. doi: 10.1016/j.molbiopara.2021.111395. Epub 2021 Jul 9.

Abstract

Rhodesain is the generic name for the cathepsin L-like peptidase of Trypanosoma brucei rhodesiense. The term rhodesain was derived from the subspecies epithet rhodesiense which itself originated form Rhodesia, a historical region in southern Africa named after the 19th century British imperialist and white supremacist Cecil Rhodes. This tainting could be grounds for discontinuing the name, however, there are also scientific grounds. Specifically, protein sequence comparisons and frequency-based difference profiling reveal that rhodesain is essentially identical (99.87-98.44%) to the cathepsin L-like peptidases of both T. b. brucei and T. b. gambiense. Accordingly, and based on a previously proposed terminology for kinetoplastid C1 peptidases (Caffrey and Steverding, 2009), we suggest the use of the formal term, TbrCATL, to denote the cathepsin L-like peptidases of the T. brucei subspecies. The earlier and informal term, 'brucipain', could also be used.

摘要

罗得西亚蛋白酶是布氏罗得西亚锥虫组织蛋白酶L样肽酶的通用名称。“罗得西亚蛋白酶”一词源于亚种名称“罗得西亚”,该名称本身源自罗德西亚,这是非洲南部的一个历史地区,以19世纪英国帝国主义者和白人至上主义者塞西尔·罗兹命名。然而,这一污点可能成为停用该名称的理由,不过也有科学依据。具体而言,蛋白质序列比较和基于频率的差异分析表明,罗得西亚蛋白酶与布氏布氏锥虫和布氏冈比亚锥虫的组织蛋白酶L样肽酶基本相同(99.87 - 98.44%)。因此,基于之前提出的动基体C1肽酶术语(卡弗里和施特弗丁,2009年),我们建议使用正式术语TbrCATL来表示布氏锥虫亚种的组织蛋白酶L样肽酶。也可以使用更早的非正式术语“布鲁西蛋白酶”。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验