Pathology and Laboratory Medicine, Aga Khan University, Karachi, Sindh, Pakistan
Obstetrics & Gynecology, Aga Khan University Hospital, Karachi, Sindh, Pakistan.
BMJ Case Rep. 2021 Jul 12;14(7):e243989. doi: 10.1136/bcr-2021-243989.
We report a case of an elderly woman, presenting with vesicouterine fistula and enlarged axillary lymph nodes. She had been diagnosed with cervical squamous cell carcinoma (SCC) in April 2015, for which she had received brachytherapy and concurrent chemoradiation therapy. The presence of enlarged axillary lymph nodes raised a suspicion for breast cancer with axillary metastases, but the bilateral mammograms did not show any discrete lesion in both breasts. The biopsy from axillary lymph node showed metastatic SCC, with block positivity for P16, confirming the origin from known cervical primary. Axillary lymph nodes are the least likely to be involved by tumours arising in the pelvis, as the lymphatic drainage of this region goes directly to the systemic circulation via the para-aortic lymph nodes and thoracic ducts. A complete clinical history is essential in such cases, to avoid misdiagnosis. Positron emission tomography CT helps in this regard.
我们报告一例老年女性患者,表现为膀胱-子宫瘘和腋窝淋巴结肿大。她于 2015 年 4 月被诊断为宫颈鳞状细胞癌(SCC),接受了近距离放射治疗和同期放化疗。腋窝淋巴结肿大提示乳腺癌伴腋窝转移,但双侧乳房 X 线照片均未显示出任何离散性病变。腋窝淋巴结活检显示转移性 SCC,P16 阳性,证实来源于已知的宫颈原发灶。来自骨盆的肿瘤最不可能累及腋窝淋巴结,因为该区域的淋巴引流通过腹主动脉旁淋巴结和胸导管直接进入全身循环。在这种情况下,完整的临床病史至关重要,以避免误诊。正电子发射断层扫描 CT 有助于这方面的诊断。