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浅析糖纳米技术在现代诊断学和治疗学中的作用。

A brief insight to the role of glyconanotechnology in modern day diagnostics and therapeutics.

机构信息

Sweet Lab, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, 741246, India.

出版信息

Carbohydr Res. 2021 Sep;507:108394. doi: 10.1016/j.carres.2021.108394. Epub 2021 Jul 2.

Abstract

Carbohydrate-protein and carbohydrate-carbohydrate interactions are very important for various biological processes. Although the magnitude of these interactions is low compared to that of protein-protein interaction, the magnitude can be boosted by multivalent approach known as glycocluster effect. Nanoparticle platform is one of the best ways to present diverse glycoforms in multivalent manner and thus, the field of glyconanotechnology has emerged as an important field of research considering their potential applications in diagnostics and therapeutics. Considerable advances in the field have been achieved through development of novel techniques, use of diverse metallic and non-metallic cores for better efficacy and application of ever-increasing number of carbohydrate ligands for site-specific interaction. The present review encompasses the recent developments in the area of glyconanotechnology and their future promise as diagnostic and therapeutic tools.

摘要

碳水化合物-蛋白质和碳水化合物-碳水化合物的相互作用对于各种生物过程非常重要。尽管与蛋白质-蛋白质相互作用相比,这些相互作用的强度较低,但通过多价方法(即糖簇效应)可以增强其强度。纳米颗粒平台是在多价方式下呈现多种糖型的最佳方法之一,因此,考虑到它们在诊断和治疗方面的潜在应用,糖纳米技术领域已成为一个重要的研究领域。通过开发新技术、使用各种金属和非金属核心以提高疗效以及应用越来越多的特定于位点的碳水化合物配体,该领域取得了相当大的进展。本综述涵盖了糖纳米技术领域的最新进展及其作为诊断和治疗工具的未来前景。

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