组蛋白去乙酰化酶 3 在实体器官损伤发病机制中的关键作用。
The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury.
机构信息
Department of Thoracic Surgery, Renmin Hospital of Wuhan University, 430060, Wuhan, China.
出版信息
Cell Death Dis. 2021 Jul 23;12(8):734. doi: 10.1038/s41419-021-04019-6.
Histone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.
组蛋白去乙酰化酶 3（HDAC3）在染色质重塑中发挥着关键作用，而后者又调节基因转录。因此，HDAC3 与多种疾病有关，包括缺血性损伤、纤维化、神经退行性变、感染和炎症状态。此外，HDAC3 通过调节昼夜节律、代谢和发育在生理条件下发挥重要作用。在这篇综述中，我们总结了 HDAC3 的生理功能及其在器官损伤中的作用的现有知识。我们还讨论了 HDAC3 在各种疾病中的治疗价值。
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