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CAPABLE项目在多项随机试验中改善了残疾状况。

CAPABLE program improves disability in multiple randomized trials.

作者信息

Szanton Sarah L, Leff Bruce, Li Qiwei, Breysse Jill, Spoelstra Sandra, Kell Judith, Purvis James, Xue Qian-Li, Wilson Jonathan, Gitlin Laura N

机构信息

Johns Hopkins School of Nursing, Baltimore, Maryland, USA.

Johns Hopkins School of Public Health, Baltimore, Maryland, USA.

出版信息

J Am Geriatr Soc. 2021 Dec;69(12):3631-3640. doi: 10.1111/jgs.17383. Epub 2021 Jul 27.

Abstract

BACKGROUND

Programs to reduce disability are crucial to the quality of life for older adults with disabilities. Reducing disability is also important to avert unnecessary and costly hospitalizations, relocation, or nursing home placements. Few programs reduce disability and few have been replicated and scaled beyond initial research settings. CAPABLE is one such program initially tested in a randomized control trial and has now been tested and replicated in multiple settings. CAPABLE, a 10-session, home-based interprofessional program, provides an occupational therapist, nurse, and handyworker to address older adults' self-identified functional goals by enhancing individual capacity and home environmental supports. We examine evidence for the CAPABLE program from clinical trials embedded in different health systems on outcomes that matter most to older adults with disability.

METHODS

Six trials with peer-reviewed publications or reports were identified and included in this review. Participants' outcomes included basic and instrumental activities of daily living (ADLs, IADLs), fall efficacy, depression, pain, and cost savings.

RESULTS

A total of 1144 low-income, community-dwelling older adults with disabilities and 4236 matched comparators were included in the six trials. Participants were on average ≥74-79 years old, cognitively intact, and with self-reported difficulty with ≥1 ADLs. All six studies demonstrated improvements in ADLs and IADLs, with small to strong effect sizes (0.41-1.47). Outcomes for other factors were mixed. Studies implementing the full-tested dose of CAPABLE showed more improvement in ADLS and cost savings than studies implementing a decreased dose.

CONCLUSIONS

The CAPABLE program resulted in substantial improvements in ADLs and IADLs in all six trials with other outcomes varying across studies. A dose lower than the original protocol tested resulted in less benefit. The four studies examining cost showed that CAPABLE saved more than it costs to implement.

摘要

背景

减少残疾的项目对于残疾老年人的生活质量至关重要。减少残疾对于避免不必要的、昂贵的住院治疗、搬迁或养老院安置也很重要。很少有项目能减少残疾,而且很少有项目能在最初的研究环境之外进行复制和推广。“赋能老年人促进独立生活能力”(CAPABLE)项目就是这样一个最初在随机对照试验中进行测试的项目,现在已经在多个环境中进行了测试和复制。CAPABLE项目是一个为期10节的居家跨专业项目,由职业治疗师、护士和杂工提供服务,通过增强个人能力和家庭环境支持来实现老年人自我确定的功能目标。我们从嵌入不同卫生系统的临床试验中,研究CAPABLE项目对残疾老年人最重要的结局的证据。

方法

确定了六项有同行评审出版物或报告的试验并纳入本综述。参与者的结局包括基本日常生活活动和工具性日常生活活动(ADL、IADL)、跌倒效能、抑郁、疼痛和成本节约。

结果

六项试验共纳入了1144名低收入、居住在社区的残疾老年人和4236名匹配的对照者。参与者平均年龄≥74 - 79岁,认知功能完好,且自我报告在≥1项ADL方面有困难。所有六项研究均表明ADL和IADL有改善,效应大小从小到强(0.41 - 1.47)。其他因素的结局则好坏参半。实施完整测试剂量CAPABLE的研究在ADL改善和成本节约方面比实施减少剂量的研究更显著。

结论

在所有六项试验中,CAPABLE项目都使ADL和IADL有了显著改善,其他结局在不同研究中有所不同。低于原始测试方案的剂量带来的益处较少。四项考察成本的研究表明,CAPABLE项目的节省超过了实施成本。

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