和的叶提取物及其馏分的抗疟活性研究及其高效液相色谱分析。 （你提供的原文中“和”表述不完整，可能影响准确理解。）
Study of the Antimalarial Activity of the Leaf Extracts and Fractions of and and Their HPLC Analysis.
作者信息
Uzor Philip F, Onyishi Chukwuebuka K, Omaliko Adaeze P, Nworgu Somtochukwu A, Ugwu Onyemaechi H, Nwodo Ngozi J
机构信息
Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka 410001, Enugu, Nigeria.
出版信息
Evid Based Complement Alternat Med. 2021 Jul 17;2021:5218294. doi: 10.1155/2021/5218294. eCollection 2021.
In the present study, the antimalarial activity of the extracts and fractions of the leaves of and as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol, and water fractions. The extracts and fractions were tested against in both curative and suppressive antimalarial mouse models. Their major phytochemical composition was studied by the standard chemical tests and HPLC analysis. The extracts and fractions of and demonstrated significant ( < 0.05) maximal plasmodial inhibition as 52.16 ± 2.77% and 57.10 ± 1.98%, respectively, and chemosuppression of parasitemia as 64.01 ± 0.08% and 71.99 ± 0.06%, respectively. The major secondary metabolites identified in the plants include alkaloids, flavonoids, and saponins. It was concluded that and possess promising antimalarial activity and they are potential sources of new lead compounds against malaria.
在本研究中，对[植物名称1]和[植物名称2]叶片的提取物及其馏分的抗疟活性以及它们的植物化学成分进行了检测。将每种植物提取物依次分馏，得到己烷、乙酸乙酯、甲醇和水馏分。在治疗性和抑制性抗疟小鼠模型中，对提取物和馏分进行了针对[疟原虫名称]的测试。通过标准化学测试和高效液相色谱分析研究了它们的主要植物化学成分。[植物名称1]和[植物名称2]的提取物和馏分分别表现出显著（P < 0.05）的最大疟原虫抑制率，分别为52.16±2.77%和57.10±1.98%，以及对寄生虫血症的化学抑制率，分别为64.01±0.08%和71.99±0.06%。在这些植物中鉴定出的主要次生代谢产物包括生物碱、黄酮类化合物和皂苷。得出的结论是，[植物名称1]和[植物名称2]具有有前景的抗疟活性，它们是抗疟新先导化合物的潜在来源。
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