钴茂硒醇金（I）配合物：合成、光谱、结构及抗癌性能
Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties.
作者信息
Menia Daniel, Kopacka Holger, Wurst Klaus, Müller Thomas, Lippmann Petra, Ott Ingo, Bildstein Benno
机构信息
Institute of General, Inorganic and Theoretical Chemistry University of Innsbruck Center for Chemistry and Biomedicine Innrain 80-82 6020 Innsbruck Austria.
Institute of Organic Chemistry University of Innsbruck Center for Chemistry and Biomedicine Innrain 80-82 6020 Innsbruck Austria.
出版信息
Eur J Inorg Chem. 2021 Jul 22;2021(27):2784-2786. doi: 10.1002/ejic.202100379. Epub 2021 Jun 15.
Cobaltoceniumselenolate is an unusual, highly air-sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero- and homoleptic gold complexes are highly colored, air-stable compounds, which were characterized by H/C/P/Se NMR, IR, UV-Vis, HR-MS and single crystal XRD. Cytotoxicity of these polar, water-soluble complexes was studied against various standard cancer cell lines (A549MDA-MB-231, HT-29) revealing good anticancer activity of all three complexes.
硒醇钴茂是一种不同寻常的、对空气高度敏感的中离子化合物，含有一个非常软的阴离子硒供体原子。在此，我们探索了它与金（I）金属中心的配位化学，并表明其杂配和均配金配合物是颜色鲜艳、空气稳定的化合物，通过H/C/P/Se NMR、IR、UV-Vis、HR-MS和单晶XRD对其进行了表征。研究了这些极性水溶性配合物对各种标准癌细胞系（A549、MDA-MB-231、HT-29）的细胞毒性，结果表明这三种配合物均具有良好的抗癌活性。
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