长链非编码RNA：化疗药物所致心脏毒性中的潜在作用因子
Long Non-coding RNAs: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs.
作者信息
Amrovani Mehran, Mohammadtaghizadeh Mohammadjavad, Aghaali Mahsa Karimzadeh, Zamanifard Somayeh, Alqasi Arash, Sanei Mozhdeh
机构信息
High Institute for Education and Research in Transfusion Medicine, Tehran, Iran.
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Cardiovasc Toxicol. 2022 Mar;22(3):191-206. doi: 10.1007/s12012-021-09681-y. Epub 2021 Aug 20.
One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the pathogenesis of cardiotoxicity; one of the most important of which is long non-coding RNAs (lncRNAs). lncRNA has 200-1000 nucleotides. It is involved in important processes such as cell proliferation, regeneration and apoptosis; today it is used as a prognostic and diagnostic factor. A, various drugs by acting on lncRNAs can affect cells. Therefore, by accurately identifying IncRNAs function, we can play an effective role in preventing the development of cardiotoxicity-induced chemotherapy drugs, and use them as a therapeutic strategy to improve clinical symptoms and increase patient survival.
化疗最重要的副作用之一是心血管并发症，如心脏毒性。心脏毒性的发病机制涉及许多因素；其中最重要的因素之一是长链非编码RNA（lncRNAs）。lncRNA有200 - 1000个核苷酸。它参与细胞增殖、再生和凋亡等重要过程；如今它被用作一种预后和诊断因素。A，各种药物通过作用于lncRNAs可影响细胞。因此，通过准确识别lncRNAs的功能，我们可以在预防化疗药物引起的心脏毒性发展方面发挥有效作用，并将它们用作改善临床症状和提高患者生存率的治疗策略。
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