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新型抗癌肽在癌症敏感治疗中的生物医学相关性。

Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer.

机构信息

Environmental Biotechnology Laboratory, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.

Department of Plant Sciences, Qwaqwa Campus, University of the Free State, Phuthaditjhaba 9866, South Africa.

出版信息

Biomolecules. 2021 Jul 29;11(8):1120. doi: 10.3390/biom11081120.

Abstract

The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host defense peptides, also known as antimicrobial peptides, which have emerged as therapeutic and diagnostic candidates due to several compensatory advantages over the non-specificity of the current treatment regimens. This review aimed to highlight the ravaging incidence of cancer, the use of ACPs in cancer treatment with their mechanisms, ACP discovery and delivery methods, and the limitations for their use. This would create awareness for identifying more ACPs with better specificity, accuracy and sensitivity towards the disease. It would also promote their efficacious utilization in biotechnology, medical sciences and molecular biology to ease the severity of the disease and enable the patients living with these conditions to develop an accommodating lifestyle.

摘要

全球癌症死亡率和经济损失的增加,需要谨慎寻求具有比传统疗法更具补偿优势的治疗药物。抗癌肽(ACPs)是宿主防御肽的一个子集,也称为抗菌肽,由于其具有比当前治疗方案的非特异性更高的多种补偿优势,因此已成为治疗和诊断的候选物。本综述旨在强调癌症的肆虐发病率,ACPs 在癌症治疗中的应用及其机制,ACPs 的发现和传递方法,以及其使用的局限性。这将有助于提高人们对具有更好特异性,准确性和对疾病敏感性的更多 ACP 的认识。它还将促进它们在生物技术,医学科学和分子生物学中的有效利用,以减轻疾病的严重程度,并使患有这些疾病的患者能够适应生活方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57b3/8394746/28da7b93c881/biomolecules-11-01120-g001.jpg

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