肠性肢端皮炎 1 蛋白在结直肠腺癌中增加。
Ethylmalonic Encephalopathy 1 Protein Is Increased in Colorectal Adenocarcinoma.
机构信息
Department of Pathology and Translational Pathobiology, LSU Health Sciences Center, Shreveport, LA, U.S.A.
Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A.
出版信息
Anticancer Res. 2021 Oct;41(10):4719-4723. doi: 10.21873/anticanres.15286.
BACKGROUND/AIM: Ethylmalonic encephalopathy 1 protein (ETHE1) plays an important role in sulfide catabolism and polysulfide formation. As sulfides and polysulfides have recently been identified as playing important roles in cancer, we hypothesized that ETHE1 expression would be increased in colon cancer.
MATERIALS AND METHODS
We used tissue microarray analysis to compare ETHE1 expression in benign colonic epithelium compared to colonic adenocarcinoma. In total, 26 benign colonic epithelial samples were compared to 122 cases of colonic adenocarcinomas.
RESULTS
Compared to benign colonic epithelium, ETHE1 expression was significantly increased (~two-fold) in colonic adenocarcinoma. Additionally, this expression increased with increasing colon cancer tumor grades.
CONCLUSION
ETHE1 expression is increased in colon cancer compared to benign colonic epithelium. These data, combined with previous studies, suggest that ETHE1 may contribute to colon carcinogenesis by promoting tumor cell bioenergetics and polysulfide formation.
背景/目的：乙基丙二酸脑病蛋白 1（ETHE1）在硫化物分解和多硫化物形成中起着重要作用。由于最近发现硫化物和多硫化物在癌症中起着重要作用，我们假设 ETHE1 的表达在结肠癌中会增加。
材料和方法
我们使用组织微阵列分析比较良性结肠上皮与结肠腺癌中 ETHE1 的表达。总共比较了 26 个良性结肠上皮样本和 122 例结肠腺癌病例。
结果
与良性结肠上皮相比，结肠腺癌中 ETHE1 的表达显著增加（约两倍）。此外，这种表达随着结肠癌肿瘤分级的增加而增加。
结论
与良性结肠上皮相比，结肠癌中 ETHE1 的表达增加。这些数据与之前的研究相结合表明，ETHE1 可能通过促进肿瘤细胞生物能量学和多硫化物形成来促进结肠癌的发生。
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