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成人顽固性湿疹性皮炎型皮肤T细胞淋巴瘤的临床医生指南

A clinician's guide to cutaneous T-cell lymphoma presenting as recalcitrant eczematous dermatitis in adults.

作者信息

Semaan Sarah, Abel Mary Kathryn, Raffi Jodie, Murase Jenny E

机构信息

Department of Dermatology, University of California, San Francisco, San Francisco, California.

Department of Dermatology, University of California, Los Angeles, Los Angeles, California.

出版信息

Int J Womens Dermatol. 2021 May 4;7(4):422-427. doi: 10.1016/j.ijwd.2021.04.004. eCollection 2021 Sep.

Abstract

Cutaneous T-cell lymphoma (CTCL) encompasses a group of low-grade, non-Hodgkin lymphoma, including mycosis fungoides and Sézary syndrome. Diagnosis of CTCL can be challenging given the prolonged, gradual onset and shared characteristics with many benign inflammatory skin diseases. In this case series, we describe four unique cases of patients with chronic, recalcitrant eczematous dermatitis who presented for a patch-test consultation and were ultimately diagnosed with CTCL. In particular, we highlight clinical pearls to aid in distinguishing CTCL from inflammatory dermatoses and describe the diagnostic strategy to help dermatologists arrive at the diagnosis of CTCL at earlier stages of the disease.

摘要

皮肤T细胞淋巴瘤(CTCL)是一组低度恶性的非霍奇金淋巴瘤,包括蕈样肉芽肿和 Sézary 综合征。鉴于CTCL起病缓慢、病程迁延,且与许多良性炎症性皮肤病有共同特征,其诊断具有挑战性。在本病例系列中,我们描述了4例慢性、顽固性湿疹性皮炎患者的独特病例,这些患者因斑贴试验会诊前来就诊,最终被诊断为CTCL。特别是,我们强调有助于区分CTCL与炎症性皮肤病的临床要点,并描述诊断策略,以帮助皮肤科医生在疾病的早期阶段做出CTCL的诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fef/8484943/13f04b700e8c/gr1.jpg

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