德国农村一家标准护理医院医护人员中的新冠病毒病：一项前瞻性血清学-流行病学队列研究
COVID-19 among Healthcare Workers: A Prospective Serological-Epidemiological Cohort Study in a Standard Care Hospital in Rural Germany.
作者信息
Hoffmann Stephanie, Schiebel Juliane, Hufert Frank, Gremmels Heinz-Detlef, Spallek Jacob
机构信息
Department of Public Health, Institute of Health, Brandenburg University of Technology Cottbus-Senftenberg, 01968 Senftenberg, Germany.
Institute for Clinical Chemistry, Laboratory Diagnostics and Microbiology, Klinikum Niederlausitz GmbH, 01968 Senftenberg, Germany.
出版信息
Int J Environ Res Public Health. 2021 Oct 19;18(20):10999. doi: 10.3390/ijerph182010999.
Healthcare workers (HCW) play a vital role in the SARS-CoV-2 pandemic control. The aim of this study was to assess the prevalence of SARS-CoV-2 antibodies and the risk of COVID-19 infections in a cohort of HCW from four different risk groups (from intensive care unit to administration) of a hospital of a primary care level in rural Germany. The outcomes were monthly measures of antibody seroprevalence over a period of 6 months. Overall, a seroprevalence of 13.41% was determined, with significantly higher prevalence rates among HCW working in areas with more frequent contact to confirmed or suspected cases (30.30%, = 0.003). The group specific differences in the risk of infection from COVID-19 were detected, as HCW groups with frequent exposure seemed to have an increased risk (RR = 3.18, = 0.02; CI95 1.09-9.24). The findings contribute to the epidemiological understanding of the virus spread in an unvaccinated population group, which is highly relevant for the pandemic management.
医护人员在新冠疫情防控中发挥着至关重要的作用。本研究旨在评估德国农村地区一家初级保健水平医院中四个不同风险组（从重症监护病房到行政部门）的医护人员群体中新冠病毒抗体的流行率以及感染新冠病毒的风险。研究结果是在6个月期间每月对抗体血清阳性率进行的测量。总体而言，确定血清阳性率为13.41%，在与确诊或疑似病例接触更频繁的区域工作的医护人员中，流行率显著更高（30.30%，P = 0.003）。检测到不同组别的医护人员感染新冠病毒的风险存在差异，因为频繁接触的医护人员组似乎感染风险增加（相对风险 = 3.18，P = 0.02；95%置信区间1.09 - 9.24）。这些发现有助于从流行病学角度理解该病毒在未接种疫苗人群中的传播情况，这对疫情管理具有高度相关性。
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