加利福尼亚州一个大型出生队列中晚期早产儿和足月单胎新生儿脑病的危险因素。
Risk factors for neonatal encephalopathy in late preterm and term singleton births in a large California birth cohort.
机构信息
Department of Pediatrics, University of California San Diego, La Jolla California, San Diego, USA.
Rady Children's Hospital, San Diego, CA, USA.
出版信息
J Perinatol. 2022 Mar;42(3):341-347. doi: 10.1038/s41372-021-01242-z. Epub 2021 Oct 26.
OBJECTIVE
The objective was to investigate maternal and pregnancy characteristics associated with neonatal encephalopathy (NE).
STUDY DESIGN
We queried an administrative birth cohort from California between 2011 and 2017 to determine the association between each factor and NE with and without hypothermia treatment.
RESULTS
From 3 million infants born at 35 or more weeks of gestation, 6,857 cases of NE were identified (2.3 per 1000 births), 888 (13%) received therapeutic hypothermia. Risk factors for NE were stronger among cases receiving hypothermia therapy. Substance-related diagnosis, preexisting diabetes, preeclampsia, and any maternal infection were associated with a two-fold increase in risk. Maternal overweight/obesity, nulliparity, advanced maternal age, depression, gestational diabetes or hypertension, and short or long gestations also predicted NE. Young maternal age, Asian race and Hispanic ethnicity, and cannabis-related diagnosis lowered risk of NE.
CONCLUSIONS
By disseminating these results, we encourage further interrogation of these perinatal factors.
目的
本研究旨在探讨与新生儿脑病（NE）相关的产妇和妊娠特征。
研究设计
我们对 2011 年至 2017 年期间加利福尼亚州的一个行政分娩队列进行了查询，以确定每个因素与接受或不接受低温治疗的 NE 之间的关联。
结果
在 35 周或以上胎龄出生的 300 万婴儿中，发现了 6857 例 NE（每 1000 例出生 2.3 例），其中 888 例（13%）接受了治疗性低温治疗。接受低温治疗的病例中，危险因素更强。与物质相关的诊断、孕前糖尿病、子痫前期和任何母体感染与风险增加两倍相关。产妇超重/肥胖、初产妇、高龄产妇、抑郁、妊娠期糖尿病或高血压以及妊娠时间过短或过长也可预测 NE。产妇年龄较小、亚洲种族和西班牙裔以及与大麻相关的诊断可降低 NE 的风险。
结论
通过传播这些结果，我们鼓励进一步研究这些围产期因素。
Zotero 插件