人体循环系统的微流控模型：用于探索机械生物学和疾病建模的多功能平台。
Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling.
作者信息
Nguyen Ngan, Thurgood Peter, Sekar Nadia Chandra, Chen Sheng, Pirogova Elena, Peter Karlheinz, Baratchi Sara, Khoshmanesh Khashayar
机构信息
School of Engineering, RMIT University, Melbourne, Australia.
School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.
出版信息
Biophys Rev. 2021 Jul 14;13(5):769-786. doi: 10.1007/s12551-021-00815-8. eCollection 2021 Oct.
The human circulatory system is a marvelous fluidic system, which is very sensitive to biophysical and biochemical cues. The current animal and cell culture models do not recapitulate the functional properties of the human circulatory system, limiting our ability to fully understand the complex biological processes underlying the dysfunction of this multifaceted system. In this review, we discuss the unique ability of microfluidic systems to recapitulate the biophysical, biochemical, and functional properties of the human circulatory system. We also describe the remarkable capacity of microfluidic technologies for exploring the complex mechanobiology of the cardiovascular system, mechanistic studying of cardiovascular diseases, and screening cardiovascular drugs with the additional benefit of reducing the need for animal models. We also discuss opportunities for further advancement in this exciting field.
人体循环系统是一个奇妙的流体系统，对生物物理和生化信号非常敏感。当前的动物和细胞培养模型无法重现人体循环系统的功能特性，限制了我们全面理解这个多方面系统功能障碍背后复杂生物过程的能力。在本综述中，我们讨论了微流控系统重现人体循环系统生物物理、生化和功能特性的独特能力。我们还描述了微流控技术在探索心血管系统复杂力学生物学、心血管疾病机制研究以及筛选心血管药物方面的卓越能力，其额外好处是减少了对动物模型的需求。我们还讨论了这一令人兴奋的领域进一步发展的机会。
Zotero 插件