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全身麻醉下行门诊手术后,超级肥胖与病态肥胖患者的早期术后结局:一项基于国家数据库的倾向评分匹配分析

Early Postoperative Outcomes of Super Morbid Obese Compared to Morbid Obese Patients After Ambulatory Surgery Under General Anesthesia: A Propensity-Matched Analysis of a National Database.

作者信息

Hajmohamed Sherine, Patel Deeran, Apruzzese Patricia, Kendall Mark C, De Oliveira Gildasio

机构信息

From the Department of Anesthesiology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Department of Anesthesiology, Rhode Island Hospital, Providence, Rhode Island.

出版信息

Anesth Analg. 2021 Dec 1;133(6):1366-1373. doi: 10.1213/ANE.0000000000005770.

Abstract

BACKGROUND

Patients with body mass index (BMI) ≥50 kg/m2, defined as super morbid obesity, represent the fastest growing segment of patients with obesity in the United States. It is currently unknown if super morbid obese patients are at greater odds than morbid obese patients for poor outcomes after outpatient surgery. The main objective of the current investigation is to assess if super morbid obese patients are at increased odds for postoperative complications after outpatient surgery when compared to morbid obese patients.

METHODS

The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2017 to 2018 was queried to extract and compare patients who underwent outpatient surgery and were defined as either morbidly obese (BMI >40 and <50 kg/m2) or super morbidly obese (BMI ≥50 kg/m2). The primary outcome was the occurrence of medical adverse events within 72 hours of discharge. In addition, we also examine death and readmissions as secondary outcomes. A propensity-matched analysis was used to evaluate the association of BMI ≥50 kg/m2 versus BMI between 40 and 50 kg/m2 and the outcomes.

RESULTS

A total of 661,729 outpatient surgeries were included in the 2017-2018 NSQIP database. Of those, 7160 with a BMI ≥50 kg/m2 were successfully matched to 7160 with a BMI <50 and ≥40 kg/m2. After matching, 17 of 7160 (0.24%) super morbid obese patients had 3-day medical complications compared to 15 of 7160 (0.21%) morbid obese patients (odds ratio [OR; 95% confidence interval {CI}] = 1.13 [0.57-2.27], P = .72). The rate of 3-day surgical complications in super morbid obese patients was also not different from morbid obese patients. Thirty-five of 7160 (0.48%) super morbid obese patients were readmitted within 3 days, compared to 33 of 7160 (0.46%) morbid obese patients (OR [95% CI] = 1.06 [0.66-1.71], P = .80). When evaluated in a multivariable analysis as a continuous variable (1 unit increase in BMI) in all patients, BMI ≥40 kg/m2 was not significantly associated with overall medical complications (OR [95% CI] = 1.00 [0.98-1.04], P = .87), overall surgical complication (OR [95% CI] = 1.02 [0.98-1.06], P = .23), or readmissions (OR [95% CI] = 0.99 [0.97-1.02], P = .8).

CONCLUSIONS

Super morbid obesity is not associated with higher rates of early postoperative complications when compared to morbid obese patients. Specifically, early pulmonary complications were very low after outpatient surgery. Super morbid obese patients should not be excluded from outpatient procedures based on a BMI cutoff alone.

摘要

背景

体重指数(BMI)≥50kg/m²的患者被定义为超级病态肥胖,是美国肥胖患者中增长最快的群体。目前尚不清楚超级病态肥胖患者在门诊手术后出现不良结局的几率是否高于病态肥胖患者。本研究的主要目的是评估与病态肥胖患者相比,超级病态肥胖患者在门诊手术后发生术后并发症的几率是否增加。

方法

查询2017年至2018年美国外科医师学会国家外科质量改进计划(ACS-NSQIP)数据库,以提取并比较接受门诊手术且被定义为病态肥胖(BMI>40且<50kg/m²)或超级病态肥胖(BMI≥50kg/m²)的患者。主要结局是出院后72小时内发生的医疗不良事件。此外,我们还将死亡和再入院作为次要结局进行研究。采用倾向评分匹配分析来评估BMI≥50kg/m²与40至50kg/m²之间的BMI与结局之间的关联。

结果

2017 - 2018年NSQIP数据库中共纳入661,729例门诊手术。其中,7160例BMI≥50kg/m²的患者与7160例BMI<50且≥40kg/m²的患者成功匹配。匹配后,7160例超级病态肥胖患者中有17例(0.24%)发生了3天的医疗并发症,而7160例病态肥胖患者中有15例(0.21%)发生了此类并发症(比值比[OR;95%置信区间{CI}] = 1.13 [0.57 - 2.27],P = 0.72)。超级病态肥胖患者3天手术并发症的发生率与病态肥胖患者也无差异。7160例超级病态肥胖患者中有35例(0.48%)在3天内再次入院,而7160例病态肥胖患者中有33例(0.46%)再次入院(OR [95% CI] = 1.06 [0.66 - 1.71],P = 0.80)。在对所有患者进行多变量分析时,将BMI作为连续变量(BMI每增加1个单位)进行评估,BMI≥40kg/m²与总体医疗并发症(OR [95% CI] = 1.00 [0.98 - 1.04],P = 0.87)、总体手术并发症(OR [95% CI] = 1.02 [0.98 - 1.06],P = 0.23)或再入院(OR [95% CI] = 0.99 [0.97 - 1.02],P = 0.8)均无显著关联。

结论

与病态肥胖患者相比,超级病态肥胖与术后早期并发症的发生率较高无关。具体而言,门诊手术后早期肺部并发症非常低。不应仅基于BMI临界值将超级病态肥胖患者排除在门诊手术之外。

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