轮状病毒疫苗接种对台湾儿童轮状病毒住院的影响。
Impact of rotavirus vaccination on rotavirus hospitalizations in Taiwanese children.
机构信息
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
出版信息
Vaccine. 2021 Dec 3;39(49):7135-7139. doi: 10.1016/j.vaccine.2021.10.064. Epub 2021 Nov 14.
In 2006, two rotavirus vaccines were licensed in Taiwan but were not added to the national immunization schedule. National Health Insurance data from 2003 through 2017 were used to compare rotavirus-associated pediatric hospitalizations before and after vaccine introduction. Rotavirus hospitalization rates among children < 5 years of age significantly declined by 24% (95% confidence interval [CI] 23 - 25%) in post-vaccine compared to pre-vaccine rotavirus seasons. Rotavirus hospitalization rates declined by 42% (95% CI 39 - 44%) among infants < 12 months of age, and by 38% (95% CI 36 - 40%) among children 12 - 23 months of age. These findings suggest that, despite not being included in the national immunization schedule, rotavirus vaccines had a measurable impact on reducing rotavirus hospitalization burden among Taiwanese children.
2006 年，台湾有两种轮状病毒疫苗获得许可，但并未纳入国家免疫接种计划。本研究使用了 2003 年至 2017 年的全民健康保险数据，比较了疫苗引入前后轮状病毒相关儿科住院的情况。与疫苗引入前的轮状病毒流行季节相比，疫苗引入后 5 岁以下儿童轮状病毒住院率显著下降 24%（95%置信区间[CI]23-25%）。12 个月以下婴儿的轮状病毒住院率下降了 42%（95%CI39-44%），12-23 个月儿童的轮状病毒住院率下降了 38%（95%CI36-40%）。这些发现表明，尽管轮状病毒疫苗未纳入国家免疫接种计划，但它们对降低台湾儿童轮状病毒住院负担产生了显著影响。
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