Boye Larsen Dennis, Laursen Mogens, Simonsen Ole, Arendt-Nielsen Lars, Petersen Kristian Kjær
SMI, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark.
Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark.
Br J Pain. 2021 Nov;15(4):486-496. doi: 10.1177/20494637211005803. Epub 2021 Nov 15.
Chronic postoperative pain following total joint replacement (TJA) is a substantial clinical problem, and poor sleep may affect predictive factors for postoperative pain, such as pain catastrophizing. However, the magnitude of these associations is currently unknown. This exploratory study investigated (1) the relationship between preoperative sleep quality, clinical pain intensity, pain catastrophizing, anxiety, and depression and (2) their associations with chronic postoperative pain following TJA.
This secondary analysis from a larger randomized controlled trial included rest pain intensity (preoperative and 12 months postoperative; visual analogue scale, VAS), preoperative Pittsburgh Sleep Quality Index (PSQI), Pain Catastrophizing Scale (PCS), Hospital Anxiety and Depression Scale (HADS) data from 74 knee and 89 hip osteoarthritis (OA) patients scheduled for TJA. Poor sleepers were identified based on preoperative PSQI scores higher than 5.
Poor sleepers demonstrated higher preoperative VAS, pain catastrophizing, anxiety, and depression compared with good sleepers (all < 0.003). Preoperative PSQI (β = 0.23, = 0.006), PCS (β = 0.44, < 0.005), and anxiety (β = 0.18, = 0.036) were independent factors for preoperative VAS. Preoperative VAS (β = 0.32, < 0.005), but not preoperative sleep quality (β = -0.06, = 0.5), was an independent factor for postoperative VAS.
The OA patients reporting poor preoperative sleep quality show higher preoperative pain, pain catastrophizing, anxiety, and depression. High preoperative pain intensity, but not poor sleep quality, was associated with higher chronic postoperative pain intensity. Future studies are encouraged to explore associations between sleep and chronic postoperative pain.
全关节置换术(TJA)后的慢性术后疼痛是一个严重的临床问题,睡眠质量差可能会影响术后疼痛的预测因素,如疼痛灾难化。然而,目前尚不清楚这些关联的程度。这项探索性研究调查了(1)术前睡眠质量、临床疼痛强度、疼痛灾难化、焦虑和抑郁之间的关系,以及(2)它们与TJA术后慢性疼痛的关联。
这项来自一项更大规模随机对照试验的二次分析纳入了74例膝关节和89例髋关节骨关节炎(OA)患者的静息痛强度(术前和术后12个月;视觉模拟量表,VAS)、术前匹兹堡睡眠质量指数(PSQI)、疼痛灾难化量表(PCS)、医院焦虑抑郁量表(HADS)数据,这些患者计划接受TJA。根据术前PSQI评分高于5来确定睡眠质量差的患者。
与睡眠质量好的患者相比,睡眠质量差的患者术前VAS、疼痛灾难化、焦虑和抑郁水平更高(均P<0.003)。术前PSQI(β=0.23,P=0.006)、PCS(β=0.44,P<0.005)和焦虑(β=0.18,P=0.036)是术前VAS的独立因素。术前VAS(β=0.32,P<0.005)是术后VAS的独立因素,而术前睡眠质量(β=-0.06,P=0.5)不是。
术前睡眠质量差的OA患者术前疼痛、疼痛灾难化、焦虑和抑郁水平更高。术前疼痛强度高与术后慢性疼痛强度高相关,而睡眠质量差与之无关。鼓励未来的研究探索睡眠与术后慢性疼痛之间的关联。