激素暴露及其对乳腺癌患者发生高级别脑胶质瘤风险的抑制作用。
Hormone exposure and its suppressive effect on risk of high-grade gliomas among patients with breast cancer.
机构信息
Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA.
出版信息
J Clin Neurosci. 2021 Dec;94:200-203. doi: 10.1016/j.jocn.2021.10.029. Epub 2021 Nov 2.
BACKGROUND
Prior reports demonstrate the expression of estrogen and progesterone receptors in high-grade gliomas (HGGs), but the relationship between hormone receptor-positive disease and risk of HHGs in patients with breast cancer (BC) remains uncharacterized.
METHODS
Using the SEER 18 registries (2000-2017), we examined the temporal trend of the incidence of HGGs and BC. The standardized incidence ratio was calculated to assess the risk of subsequent HGG in BC patients.
RESULTS
During the study period, the incidence of BC and HGGs remained comparable for men and women. Among 976,134 patients with BC, we found a decreased incidence of HGGs in females, but not in males. Female BC patients with hormone receptor-positive disease were at a lower risk of developing glioblastoma and anaplastic astrocytoma.
CONCLUSION
Our study findings allude to the protective role of hormone exposure in the development of HGGs, which may lead to the development of therapies targeting hormonal pathways.
背景
先前的报告表明，高级别神经胶质瘤（HGG）中存在雌激素和孕激素受体的表达，但激素受体阳性疾病与乳腺癌（BC）患者中 HGG 风险之间的关系尚未明确。
方法
我们使用 SEER 18 登记处（2000-2017 年），研究了 HGG 和 BC 的发病率的时间趋势。通过计算标准化发病比来评估 BC 患者随后发生 HGG 的风险。
结果
在研究期间，男性和女性的 BC 和 HGG 发病率保持相当。在 976134 名 BC 患者中，我们发现女性 HGG 的发病率下降，但男性没有。患有激素受体阳性疾病的女性 BC 患者发生胶质母细胞瘤和间变性星形细胞瘤的风险较低。
结论
我们的研究结果暗示激素暴露在 HGG 发展中的保护作用，这可能导致针对激素途径的治疗方法的发展。
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