Department of Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900, Olsztyn, Poland.
Laboratory of Toxicology Science and Research, Medicine School, University of Crete, 70013, Heraklion, Crete, Greece.
Sci Rep. 2021 Dec 8;11(1):23673. doi: 10.1038/s41598-021-03152-8.
Parabens (PBs) are a group of substances commonly used in industry. They also pollute the environment, penetrate into living organisms and adversely affect various internal organs. During this study, the degree of exposure of people living in Olsztyn, a city in north eastern Poland, to selected parabens most often used in industry was studied. The chemicals under investigation included: methyl paraben-MePB, ethyl paraben-EtPB, propyl paraben-PrPB, benzyl paraben BePB and butyl paraben -BuPB. To this aim, hair samples collected from the scalps of 30 volunteers were analyzed using a liquid chromatography-mass spectrometry technique. All PBs studied were present in a high percentage of analyzed samples (from 76.7% in the case of BePB to 100% in the case of MePB and PrPB). The mean concentration levels were 4425.3 pg/mg for MeBP, 704.0 pg/mg for EtPB, 825.7 pg/mg for PrPB, 135.2 pg/mg for BePB and 154.5 pg/mg for BuPB. Significant differences in PB concentration levels between particular persons were visible. On the other hand, gender, age and artificial hair coloring did not cause statistically significant differences in PB levels. Obtained results have clearly indicated that people living in north eastern Poland are exposed to various PBs, and therefore these substances may affect their health status. However, the evaluation of PBs influence on human health requires further research.
对苯二甲酸酯(PBs)是一组广泛应用于工业领域的物质。它们也会污染环境,渗透到生物体中,并对各种内部器官产生不良影响。在这项研究中,研究了生活在波兰东北部城市奥尔什丁的人们对工业中常用的几种对苯二甲酸酯的暴露程度。研究的化学物质包括:甲基对苯二甲酸酯-MePB、乙基对苯二甲酸酯-EtPB、丙基对苯二甲酸酯-PrPB、苄基对苯二甲酸酯-BePB 和丁基对苯二甲酸酯 -BuPB。为此,使用液相色谱-质谱联用技术分析了从 30 名志愿者头皮上采集的头发样本。在所研究的所有 PBs 中,高比例的分析样本中都存在这些物质(从 BePB 的 76.7%到 MePB 和 PrPB 的 100%)。平均浓度水平分别为 MeBP 为 4425.3 pg/mg、EtPB 为 704.0 pg/mg、PrPB 为 825.7 pg/mg、BePB 为 135.2 pg/mg 和 BuPB 为 154.5 pg/mg。可以看出,不同个体之间的 PB 浓度水平存在显著差异。另一方面,性别、年龄和人工染发并没有导致 PB 水平在统计学上有显著差异。研究结果清楚地表明,生活在波兰东北部的人们会接触到各种 PBs,因此这些物质可能会影响他们的健康状况。然而,对 PBs 对人类健康的影响的评估需要进一步的研究。