c-FLIP 对外源凋亡信号的调控：靶向肿瘤网络。
Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks.
机构信息
The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Artificial Intelligence Research Institute, Moscow, Russia.
Translational Inflammation Research, Medical Faculty, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
出版信息
Trends Cancer. 2022 Mar;8(3):190-209. doi: 10.1016/j.trecan.2021.12.002. Epub 2021 Dec 29.
The extrinsic pathway is mediated by death receptors (DRs), including CD95 (APO-1/Fas) or TRAILR-1/2. Defects in apoptosis regulation lead to cancer and other malignancies. The master regulator of the DR networks is the cellular FLICE inhibitory protein (c-FLIP). In addition to its key role in apoptosis, c-FLIP may exert other cellular functions, including control of necroptosis, pyroptosis, nuclear factor κB (NF-κB) activation, and tumorigenesis. To gain further insight into the molecular mechanisms of c-FLIP action in cancer networks, we focus on the structure, isoforms, interactions, and post-translational modifications of c-FLIP. We also discuss various avenues to target c-FLIP in cancer cells for therapeutic benefit.
外源性途径由死亡受体 (DRs) 介导，包括 CD95 (APO-1/Fas) 或 TRAILR-1/2。凋亡调节缺陷可导致癌症和其他恶性肿瘤。DR 网络的主要调节因子是细胞 FLICE 抑制蛋白 (c-FLIP)。除了在凋亡中的关键作用外，c-FLIP 还可能发挥其他细胞功能，包括控制坏死、焦亡、核因子 κB (NF-κB) 激活和肿瘤发生。为了更深入地了解 c-FLIP 在癌症网络中的作用的分子机制，我们重点关注 c-FLIP 的结构、异构体、相互作用和翻译后修饰。我们还讨论了针对癌细胞中 c-FLIP 的各种靶向途径以获得治疗益处。
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