可激活的双活性氧产生探针用于双重细胞器参与的光动力治疗。
Activatable Dual ROS-Producing Probe for Dual Organelle-Engaged Photodynamic Therapy.
机构信息
State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, the Key Laboratory for Chemical Biology of Fujian Province, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Innovation Center for Cell Signaling Network, Xiamen University, Xiamen 361005, China.
Department of Nuclear Medicine, Zhongshan Hospital, Xiamen University, Xiamen 361004, China.
出版信息
ACS Appl Bio Mater. 2021 May 17;4(5):4618-4628. doi: 10.1021/acsabm.1c00354. Epub 2021 Apr 27.
Photodynamic therapy (PDT) necessitates approaches capable of increasing antitumor effects while decreasing nonspecific photodamage. We herein report an activatable probe (Glu-PyEB) comprising two distinct photosensitizers with mutually suppressed photodynamics. Activation by tumor-associated γ-glutamyltranspeptidase gives rise to a generator of superoxide radical (O) accumulated in lysosomes and a producer of singlet oxygen (O) enriched in mitochondria. This enables light-irradiation-triggered damage of lysosomes and mitochondria, robust cell death, and tumor retardation in vivo, showing the use of paired photosensitizers subjected to reciprocally suppressed photodynamics for activatable PDT.
光动力疗法（PDT）需要能够提高抗肿瘤效果，同时降低非特异性光损伤的方法。在此，我们报告了一种包含两种具有相互抑制光动力的不同光敏剂的可激活探针（Glu-PyEB）。通过肿瘤相关的γ-谷氨酰转肽酶激活产生在溶酶体中积累的超氧自由基（O）的发生器和在线粒体中富集的单线态氧（O）的产生器。这使得光照射引发的溶酶体和线粒体损伤、强大的细胞死亡以及体内肿瘤的抑制成为可能，显示出使用受相互抑制光动力控制的成对光敏剂进行可激活 PDT 的用途。
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