一种进入新型 NHC-金-酰胺配合物家族的简单合成方法及其抗肿瘤活性。
A simple synthetic entryway into new families of NHC-gold-amido complexes and their antitumor activity.
机构信息
Department of Chemistry and Centre for Sustainable Chemistry, Ghent University, Krijgslaan 281, S-3, 9000 Ghent, Belgium.
Department of Molecular Sciences and Nanosystems Università Ca' Foscari, Campus Scientifico Via Torino 155, 30174, Venezia-Mestre, Italy.
出版信息
Dalton Trans. 2022 Mar 1;51(9):3462-3471. doi: 10.1039/d2dt00239f.
A simple synthetic pathway to Au-NHC amido complexes is described. Syntheses and isolation of [Au(NHC)(NRR)] complexes, bearing various NHC ligands and NH-containing heterocycles under mild conditions are reported. The anticancer activity of these gold-complexes was investigated on three human cancer cell lines. A number of these show comparable or even better antiproliferative activity than cisplatin. Noteworthy is the non-toxicity of most of the complexes on normal cells.
描述了一种简单的 Au-NHC 酰胺配合物的合成途径。报道了在温和条件下，通过合成和分离具有各种 NHC 配体和含 NH 杂环的[Au（NHC）（NRR）]配合物。研究了这些金配合物对三种人癌细胞系的抗癌活性。其中一些配合物的抗增殖活性与顺铂相当，甚至更好。值得注意的是，大多数配合物对正常细胞没有毒性。
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