脂肪滴包被蛋白概述。
Perilipins at a glance.
机构信息
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
J Cell Sci. 2022 Mar 1;135(5). doi: 10.1242/jcs.259501. Epub 2022 Mar 9.
Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy metabolism, membrane synthesis and production of lipid-derived signaling molecules. While compositional differences in the phospholipid monolayer or neutral lipid core of LDs impact their metabolism and function, the proteome of LDs has emerged as a major influencer in all aspects of LD biology. The perilipins (PLINs) are the most studied and abundant proteins residing on the LD surface. This Cell Science at a Glance and the accompanying poster summarize our current knowledge of the common and unique features of the mammalian PLIN family of proteins, the mechanisms through which they affect cell metabolism and signaling, and their links to disease.
脂滴（LDs）是普遍存在的细胞器，它们储存和供应脂质用于能量代谢、膜合成和脂质衍生的信号分子的产生。虽然 LDs 中磷脂单层或中性脂质核心的组成差异会影响其代谢和功能，但 LD 的蛋白质组已成为 LD 生物学各个方面的主要影响因素。围脂滴蛋白（PLINs）是 LD 表面上研究最多和最丰富的蛋白质。这篇《细胞科学一瞥》和配套海报总结了我们目前对哺乳动物 PLIN 蛋白家族的常见和独特特征的认识，它们影响细胞代谢和信号转导的机制，以及它们与疾病的联系。
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