NFAT 在血液系统恶性肿瘤发病机制和靶向治疗中的作用。
The role of NFAT in the pathogenesis and targeted therapy of hematological malignancies.
机构信息
Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China; Tianhe Nuoya Bio-engineering Co. Ltd, Guangzhou, 510663, China.
出版信息
Eur J Pharmacol. 2022 Apr 15;921:174889. doi: 10.1016/j.ejphar.2022.174889. Epub 2022 Mar 12.
The nuclear factor of activated T cells (NFAT) family is well known for the survival of hemopoietic cells and plays an important role in the immune response. In recent decades, NFAT alteration was discovered in hematological malignancies, suggesting that targeted NFAT therapy may be a promising strategy for the treatment of hematological malignancies. In this review, we present an overview of the NFAT signaling pathway in lymphocytes as well as aberrant NFAT in hematological malignancies. Moreover, therapeutically targeting NFAT in hematological malignancies is also discussed in this review.
核因子活化 T 细胞（NFAT）家族因其对造血细胞的存活作用而闻名，在免疫反应中发挥着重要作用。近几十年来，人们发现 NFAT 在血液恶性肿瘤中发生改变，这表明靶向 NFAT 治疗可能是血液恶性肿瘤治疗的一种有前途的策略。在这篇综述中，我们介绍了淋巴细胞中 NFAT 信号通路以及血液恶性肿瘤中异常的 NFAT 情况。此外，本文还讨论了血液恶性肿瘤中靶向 NFAT 的治疗方法。
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