Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Support Care Cancer. 2022 Jun;30(6):5539-5549. doi: 10.1007/s00520-022-06961-3. Epub 2022 Mar 23.
Lung cancer was often accompanied by depression and anxiety. Nowadays, most investigations for depression and anxiety were concentrated in western medical hospitals, while few related studies have been carried out in the tradition Chinese medicine (TCM) ward. It was necessary to understand the proportion and related factors of depression and anxiety in the inpatients with lung cancer in TCM hospital.
This study adopted cross-sectional research method, which enrolled a total of 222 inpatients with lung cancer in TCM hospital. PHQ-9 and GAD-7 scales were used to assess depression and anxiety for the inpatients, respectively. Demographic and clinical data were also collected. Statistical methods of the univariate analysis and the multivariate logistic regression model were used.
The proportion of depression and anxiety in the inpatients with lung cancer were 58.1% and 34.2%, respectively. Multivariate logistic regression analysis prompted that the common related factor of depression and anxiety was the symptom of insomnia(odds ratio [OR] 3.274, 95%CI 1.723-6.219; OR 2.201, 95%CI 1.132-4.277). Constipation and gender were the two anther-related factors of depression(OR 1.458, 95%CI 0.372-1.606; OR 1.298, 95%CI 0.151-1.588).
Depression and anxiety were common for the inpatients with lung cancer in TCM hospital. Gender, insomnia, and constipation were related factors for depression, and insomnia was related factor for anxiety. Therefore, medical workers should pay close attention to the emotional changes of these high-risk patients and intervene the symptoms as early as possible.
肺癌常伴有抑郁和焦虑。目前,大多数关于抑郁和焦虑的研究都集中在西医医院,而中医医院对抑郁和焦虑的相关研究较少。有必要了解中医医院肺癌住院患者中抑郁和焦虑的比例及相关因素。
本研究采用横断面研究方法,共纳入中医医院 222 例肺癌住院患者。采用 PHQ-9 和 GAD-7 量表分别评估患者的抑郁和焦虑状况,同时收集患者的人口统计学和临床资料。采用单因素分析和多因素 logistic 回归模型进行统计学分析。
肺癌住院患者中抑郁和焦虑的比例分别为 58.1%和 34.2%。多因素 logistic 回归分析提示,失眠症状是抑郁和焦虑的共同相关因素(OR=3.274,95%CI 1.723-6.219;OR=2.201,95%CI 1.132-4.277)。便秘和性别是抑郁的另外两个相关因素(OR=1.458,95%CI 0.372-1.606;OR=1.298,95%CI 0.151-1.588)。
中医医院肺癌住院患者中抑郁和焦虑较为常见。性别、失眠和便秘是抑郁的相关因素,失眠是焦虑的相关因素。因此,医务人员应密切关注这些高危患者的情绪变化,并尽早干预症状。