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藻类代谢产物可成为对抗新冠疫情的免疫增强剂。

Algal Metabolites Can Be an Immune Booster against COVID-19 Pandemic.

作者信息

Kumar Ajay, Singh Rahul Prasad, Kumar Indrajeet, Yadav Priya, Singh Sandeep Kumar, Singh Prashant Kumar, Gupta Rajan Kumar, Singh Shiv Mohan, Kesawat Mahipal Singh, Saratale Ganesh Dattatraya, Chung Sang-Min, Kumar Manu

机构信息

Volcani Center, Department of Postharvest Science, Agriculture Research Organization, Rishon LeZion 7505101, Israel.

Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi 221005, India.

出版信息

Antioxidants (Basel). 2022 Feb 24;11(3):452. doi: 10.3390/antiox11030452.

Abstract

The world has faced the challenges of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for the last two years, first diagnosed at the end of 2019 in Wuhan and widely distributed worldwide. As a result, the WHO has proclaimed the illness brought on by this virus to be a global pandemic. To combat COVID-19, researcher communities continuously develop and implement rapid diagnoses, safe and effective vaccinations and other alternative therapeutic procedures. However, synthetic drug-related side effects and high costs have piqued scientists' interest in natural product-based therapies and medicines. In this regard, antiviral substances derived from natural resources and some medicines have seen a boom in popularity. For instance, algae are a rich source of compounds such as lectins and sulfated polysaccharides, which have potent antiviral and immunity-boosting properties. Moreover, Algae-derived compounds or metabolites can be used as antibodies and vaccine raw materials against COVID-19. Furthermore, some algal species can boost immunity, reduce viral activity in humans and be recommended for usage as a COVID-19 preventative measure. However, this field of study is still in its early stages of development. Therefore, this review addresses critical characteristics of algal metabolites, their antioxidant potential and therapeutic potential in COVID-19.

摘要

在过去两年里,世界面临着严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的挑战,该病毒于2019年底在武汉首次被诊断出,并在全球广泛传播。因此,世界卫生组织宣布由这种病毒引发的疾病为全球大流行。为抗击新冠肺炎,研究人员不断研发并实施快速诊断、安全有效的疫苗接种以及其他替代治疗方法。然而,合成药物的副作用和高昂成本激发了科学家对基于天然产物的疗法和药物的兴趣。在这方面,源自自然资源的抗病毒物质和一些药物大受欢迎。例如,藻类富含凝集素和硫酸化多糖等化合物,这些化合物具有强大的抗病毒和增强免疫力的特性。此外,藻类衍生的化合物或代谢物可作为针对新冠肺炎的抗体和疫苗原料。此外,一些藻类物种可以增强免疫力,降低人类体内的病毒活性,并被推荐作为预防新冠肺炎的措施使用。然而,这一研究领域仍处于早期发展阶段。因此,本综述阐述了藻类代谢物的关键特性、它们的抗氧化潜力以及在新冠肺炎治疗中的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f8/8944855/f39bc05bac89/antioxidants-11-00452-g001.jpg

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