精神分裂症的心理理论神经通路：系统综述和荟萃分析。
Neuropathways of theory of mind in schizophrenia: A systematic review and meta-analysis.
机构信息
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, People's Republic of China.
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, People's Republic of China; Mental Health Research Centre, The Hong Kong Polytechnic University, Hung Hom, Kowloon, People's Republic of China.
出版信息
Neurosci Biobehav Rev. 2022 Jun;137:104625. doi: 10.1016/j.neubiorev.2022.104625. Epub 2022 Mar 24.
BACKGROUND
Social cognition is significantly associated with daily functioning in patients with schizophrenia. Its neural basis remains unknown.
METHODS
A systematic literature search was performed. Studies using imaging to measure theory of mind (ToM) in schizophrenia were identified. Imaging data were synthesized using the seed-based d mapping approach. Potential neuropathways were hypothesized based on the identified brain regions activated during ToM tasks.
RESULTS
A total of 25 studies were included in the present study. Compared with healthy people, patients with schizophrenia showed hyperactivations in superior longitudinal fasciculus II and hypoactivations in superior frontal gyrus, precuneus and cuneus, and precentral gyrus during ToM tasks. The primary brain regions involved in the potential neuropathways in schizophrenia were the middle temporal gyrus, superior and inferior frontal gyrus, and supplementary motor areas.
CONCLUSION
Deactivated brain regions in schizophrenia overlapped with the default mode and salience networks. Our findings shed light on how to develop a diagnostic tool for deficits in social cognition using neuroimaging techniques and effective therapeutic interventions to rectify dysfunction in schizophrenia.
背景
社会认知与精神分裂症患者的日常功能显著相关。但其神经基础尚不清楚。
方法
进行了系统的文献检索。确定了使用影像学测量精神分裂症患者心理理论（ToM）的研究。使用基于种子的 d 映射方法综合影像学数据。根据在 ToM 任务中激活的识别脑区，假设潜在的神经通路。
结果
本研究共纳入 25 项研究。与健康人相比，精神分裂症患者在执行心理理论任务时，上纵束 II 呈过度活跃，额上回、楔前叶和楔叶以及中央前回呈活动低下。精神分裂症潜在神经通路的主要脑区包括颞中回、额上回和额下回以及辅助运动区。
结论
精神分裂症患者的失活脑区与默认模式网络和突显网络重叠。我们的研究结果为使用神经影像学技术开发社会认知缺陷的诊断工具以及纠正精神分裂症功能障碍的有效治疗干预措施提供了思路。
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