miR-638：一种具有治疗潜力的有望成为癌症生物标志物的物质。

miR-638: A Promising Cancer Biomarker with Therapeutic Potential.

作者信息

Hasheminasabgorji Elham, Mishan Mohammad Amir, Tabari Mohammad Amin Khazeei, Bagheri Abouzar

机构信息

Department of Clinical Biochemistry and Medical Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Arnie Charbonneau Cancer Institute, Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

出版信息

Curr Mol Med. 2023;23(5):377-389. doi: 10.2174/1566524022666220405125900.

DOI:10.2174/1566524022666220405125900

PMID:35382724

Abstract

BACKGROUND

There is an unmet need to improve the diagnosis of cancer with precise treatment strategies. Therefore, more powerful diagnostic, prognostic, and therapeutic biomarkers are needed to overcome tumor cells. microRNAs (miRNAs, miRs), as a class of small non-coding RNAs, play essential roles in cancer through the tumor-suppressive or oncogenic effects by post-transcriptional regulation of their targets. Many studies have provided shreds of evidence on aberrantly expressed miRNAs in numerous cancers and have shown that miRNAs could play potential roles as diagnostic, prognostic, and even therapeutic biomarkers in patients with cancers. Findings have revealed that miR-638 over or underexpression might play a critical role in cancer initiation, development, and progression. However, the mechanistic effects of miR-638 on cancer cells are still controversial.

CONCLUSION

In the present review, we have focused on the diagnostic, prognostic, and therapeutic potentials of miR-638 and discussed its mechanistic roles in various types of cancers.

摘要

背景

对于采用精确治疗策略改善癌症诊断存在未满足的需求。因此，需要更强大的诊断、预后和治疗生物标志物来攻克肿瘤细胞。微小RNA（miRNA，miR）作为一类小的非编码RNA，通过对其靶标的转录后调控发挥肿瘤抑制或致癌作用，在癌症中起着至关重要的作用。许多研究提供了大量证据表明多种癌症中存在miRNA异常表达，并表明miRNA在癌症患者中可能作为诊断、预后甚至治疗生物标志物发挥潜在作用。研究结果显示，miR-638的过表达或低表达可能在癌症的发生、发展和进展中起关键作用。然而，miR-638对癌细胞的机制性影响仍存在争议。