COPD 和肺癌中的免疫景观的意义：吸烟与其他原因。
Implications of the Immune Landscape in COPD and Lung Cancer: Smoking Versus Other Causes.
机构信息
Division of Pulmonology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
Division of Thoracic Surgery, Department of Surgery, Medical University Graz, Graz, Austria.
出版信息
Front Immunol. 2022 Mar 21;13:846605. doi: 10.3389/fimmu.2022.846605. eCollection 2022.
Abstract
Cigarette smoking is reported in about one third of adults worldwide. A strong relationship between cigarette smoke exposure and chronic obstructive pulmonary disease (COPD) as well as lung cancer has been proven. However, about 15% of lung cancer cases, and between one fourth and one third of COPD cases, occur in never-smokers. The effects of cigarette smoke on the innate as well as the adaptive immune system have been widely investigated. It is assumed that certain immunologic features contribute to lung cancer and COPD development in the absence of smoking as the major risk factor. In this article, we review different immunological aspects of lung cancer and COPD with a special focus on non-smoking related risk factors.
摘要
据报道，全球约有三分之一的成年人吸烟。已经证明，香烟烟雾暴露与慢性阻塞性肺疾病（COPD）和肺癌之间存在很强的关联。然而，约 15%的肺癌病例和四分之一至三分之一的 COPD 病例发生在从不吸烟的人群中。香烟烟雾对先天和适应性免疫系统的影响已经得到广泛研究。人们认为，某些免疫特征有助于在没有吸烟这一主要危险因素的情况下发生肺癌和 COPD。本文综述了肺癌和 COPD 的不同免疫学方面，并特别关注与非吸烟相关的危险因素。
相似文献
1
Implications of the Immune Landscape in COPD and Lung Cancer: Smoking Versus Other Causes.
Front Immunol. 2022 Mar 21;13:846605. doi: 10.3389/fimmu.2022.846605. eCollection 2022.
2
The relationship of cigarette smoking in Japan to lung cancer, COPD, ischemic heart disease and stroke: A systematic review.
F1000Res. 2018 Feb 19;7:204. doi: 10.12688/f1000research.14002.1. eCollection 2018.
3
Childhood Cigarette Smoking and Risk of Chronic Obstructive Pulmonary Disease in Older U.S. Adults.
Am J Respir Crit Care Med. 2023 Aug 15;208(4):428-434. doi: 10.1164/rccm.202303-0476OC.
4
DNA repair as an emerging target for COPD-lung cancer overlap.
Respir Investig. 2019 Mar;57(2):111-121. doi: 10.1016/j.resinv.2018.11.005. Epub 2019 Jan 7.
5
Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD.
Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L625-L638. doi: 10.1152/ajplung.00061.2019. Epub 2019 Sep 25.
6
The occurrence of chronic obstructive pulmonary disease (COPD) in cigarette smoking families.
Przegl Lek. 2006;63(10):848-57.
7
Role of lycopene in smoke-promoted chronic obstructive pulmonary disease and lung carcinogenesis.
Arch Biochem Biophys. 2020 Aug 15;689:108439. doi: 10.1016/j.abb.2020.108439. Epub 2020 Jun 3.
8
Cigarette Smoke Induced Lung Barrier Dysfunction, EMT, and Tissue Remodeling: A Possible Link between COPD and Lung Cancer.
Biomed Res Int. 2019 Jun 24;2019:2025636. doi: 10.1155/2019/2025636. eCollection 2019.
9
Dynamics of exhaled breath temperature after smoking a cigarette and its association with lung function changes predictive of COPD risk in smokers: a cross-sectional study.
Arh Hig Rada Toksikol. 2019 Jun 1;70(2):123-129. doi: 10.2478/aiht-2019-70-3211.
10
Consequences of passive smoking in home environment.
Przegl Lek. 2007;64(10):632-41.
引用本文的文献
1
Efficacy and safety of CT-guided 125I particle implantation for the treatment of elderly lung cancer: a system evaluation and meta-analysis.
BMC Geriatr. 2025 Aug 15;25(1):629. doi: 10.1186/s12877-025-06313-w.
2
Beyond Smoking: Emerging Drivers of COPD and Their Clinical Implications in Low- and Middle-Income Countries: A Narrative Review.
J Clin Med. 2025 Jun 30;14(13):4633. doi: 10.3390/jcm14134633.
3
Unravelling the role of nanomedicine in attenuating inflammation, oxidative stress and cellular ageing in chronic obstructive pulmonary disease.
Arch Toxicol. 2025 Jun 29. doi: 10.1007/s00204-025-04116-x.
4
DC-SIGN (CD209)-mediated interactions between bacteria, lung cancer tissues, and macrophages promote cancer metastasis.
Infect Agent Cancer. 2025 Jun 21;20(1):40. doi: 10.1186/s13027-025-00667-x.
5
Immunological Insights and Therapeutic Advances in COPD: Exploring Oral Bacterial Vaccines for Immune Modulation and Clinical Improvement.
Vaccines (Basel). 2025 Jan 22;13(2):107. doi: 10.3390/vaccines13020107.
6
Chronic obstructive pulmonary disease burden attributable to tobacco and the trend change from 1990 to 2021 in China.
Tob Induc Dis. 2025 Feb 10;23. doi: 10.18332/tid/200196. eCollection 2025.
7
The Multifaceted Roles of Neutrophil Death in COPD and Lung Cancer.
J Respir Biol Transl Med. 2025 Mar;2(1). doi: 10.70322/jrbtm.2024.10022. Epub 2024 Dec 9.
8
Inhalation of patchouli essential oil alleviates airway inflammation in cigarette smoke-induced COPD mice.
Sci Rep. 2024 Dec 30;14(1):32108. doi: 10.1038/s41598-024-83852-z.
9
The causal and mediation effect of chronic obstructive pulmonary disease on lung cancer subtypes: a two-sample mendelian randomization study.
Cancer Causes Control. 2025 Jan;36(1):13-19. doi: 10.1007/s10552-024-01916-x. Epub 2024 Sep 14.
10
IL-22: A key inflammatory mediator as a biomarker and potential therapeutic target for lung cancer.
Heliyon. 2024 Aug 10;10(17):e35901. doi: 10.1016/j.heliyon.2024.e35901. eCollection 2024 Sep 15.
本文引用的文献
1
Nuclear factor-kappa B and its role in inflammatory lung disease.
Chem Biol Interact. 2021 Aug 25;345:109568. doi: 10.1016/j.cbi.2021.109568. Epub 2021 Jun 25.
2
In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system.
Clin Sci (Lond). 2021 Apr 30;135(8):1053-1063. doi: 10.1042/CS20201498.
3
The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients.
Inflammopharmacology. 2021 Feb;29(1):91-100. doi: 10.1007/s10787-020-00773-9. Epub 2020 Nov 7.
4
Cigarette smoking induces human CCR6Th17 lymphocytes senescence and VEGF-A secretion.
Sci Rep. 2020 Apr 16;10(1):6488. doi: 10.1038/s41598-020-63613-4.
5
Acute air pollution exposure alters neutrophils in never-smokers and at-risk humans.
Eur Respir J. 2020 Apr 3;55(4). doi: 10.1183/13993003.01495-2019. Print 2020 Apr.
6
Spatial association between outdoor air pollution and lung cancer incidence in China.
BMC Public Health. 2019 Oct 26;19(1):1377. doi: 10.1186/s12889-019-7740-y.
7
Short-term association between ambient air pollution and lung cancer mortality.
Environ Res. 2019 Dec;179(Pt A):108748. doi: 10.1016/j.envres.2019.108748. Epub 2019 Sep 17.
8
Human Lung Microbiome on the Way to Cancer.
J Immunol Res. 2019 Jul 29;2019:1394191. doi: 10.1155/2019/1394191. eCollection 2019.
9
Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed Subjects.
Am J Respir Crit Care Med. 2020 Jan 1;201(1):57-62. doi: 10.1164/rccm.201901-0096OC.
10
Impact of preoperative exercise therapy on surgical outcomes in lung cancer patients with or without COPD: a systematic review and meta-analysis.
Cancer Manag Res. 2019 Feb 20;11:1765-1777. doi: 10.2147/CMAR.S186432. eCollection 2019.
Zotero 插件