Department of Animal Science, Texas A&M University, College Station, TX 77843, USA.
North American Renderers Association, Alexandria, VA 22314, USA.
Exp Biol Med (Maywood). 2022 Jul;247(13):1191-1201. doi: 10.1177/15353702221082658. Epub 2022 Apr 11.
Amino acids (AAs) are required for syntheses of proteins and low-molecular-weight substances with enormous physiological importance. Since 1912, AAs have been classified as nutritionally essential amino acids (EAAs) or nonessential amino acids (NEAAs) for animals. EAAs are those AAs that are either not synthesized or insufficiently synthesized de novo in the organisms. It was assumed that all NEAAs (now known as AAs that are synthesizable in animal cells de novo [AASAs]) were formed sufficiently in animals and were not needed in diets. However, studies over the past three decades have shown that sufficient dietary AASAs (e.g. glutamine, glutamate, glycine, and proline) are necessary for the maximum growth and optimum health of pigs, chickens, and fish. Thus, the concept of "ideal protein" (protein with an optimal EAA pattern that precisely meets the physiological needs of animals), which was originally proposed in the 1950s but ignored AASAs, is not ideal in animal nutrition. Ideal diets must provide all physiologically and nutritionally essential AAs. Improved patterns of AAs in diets for swine and chickens as well as zoo and companion animals have been proposed in recent years. Animal-sourced feedstuffs supply abundant EAAs and AASAs (including glutamate, glutamine, glycine, proline, 4-hydroxyproline, and taurine) for diets of swine, poultry, fish, and crustaceans to improve their growth, development, reproduction, and health, while sustaining global animal production. Nutritionists should move beyond the "ideal protein" concept to consider optimum ratios and amounts of all proteinogenic AAs in diets for mammals, birds, and aquatic animals, and, in the case of carnivores, also taurine.
氨基酸(AAs)是合成蛋白质和具有巨大生理重要性的低分子量物质所必需的。自 1912 年以来,氨基酸被分为动物必需氨基酸(EAA)或非必需氨基酸(NEAAs)。EAA 是指那些在生物体中要么不能合成,要么不能从头合成的氨基酸。人们曾假设,所有的 NEAAs(现在称为动物细胞从头合成的可合成氨基酸 [AASAs])在动物体内都能充分形成,因此不需要在饮食中添加。然而,过去三十年来的研究表明,充足的膳食 AASAs(如谷氨酰胺、谷氨酸、甘氨酸和脯氨酸)是猪、鸡和鱼类实现最大生长和最佳健康所必需的。因此,最初在 20 世纪 50 年代提出的“理想蛋白”(具有最佳 EAA 模式的蛋白,能精确满足动物的生理需求)的概念在动物营养中并不理想。理想的饮食必须提供所有生理和营养必需的氨基酸。近年来,人们提出了改善猪和鸡以及动物园和伴侣动物饲料中氨基酸模式的建议。动物源性饲料为猪、禽、鱼和甲壳类动物的饲料提供了丰富的 EAA 和 AASAs(包括谷氨酸、谷氨酰胺、甘氨酸、脯氨酸、4-羟脯氨酸和牛磺酸),以促进它们的生长、发育、繁殖和健康,同时维持全球动物生产。营养学家应该超越“理想蛋白”的概念,考虑所有哺乳动物、鸟类和水生动物饮食中蛋白氨基酸的最佳比例和数量,对于肉食动物,还应考虑牛磺酸。