微小 RNA 调控的巨噬细胞作用对肥胖症脂肪组织功能的影响。
Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity.
机构信息
Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.
Institute for Systems Genomics, University of Connecticut, Farmington, CT 06030, USA.
出版信息
Cells. 2022 Apr 14;11(8):1336. doi: 10.3390/cells11081336.
Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversified macrophage actions are shaped through finely regulated factors, including microRNAs, which post-transcriptionally alter macrophage activation. Numerous studies have highlighted microRNAs' importance to immune function and potential as inflammation-modulatory. This review summarizes current knowledge of regulatory networks governed by microRNAs in ATMs in white adipose tissue under obesity stress.
肥胖引起的脂肪组织功能障碍是由慢性低度炎症所支撑的，并损害全身代谢健康。脂肪组织巨噬细胞（ATMs）持续引发局部炎症，但对脂肪组织稳态至关重要，发挥着具有异质性和特定小生境的功能。巨噬细胞的多样化作用是通过精细调节的因素形成的，包括 microRNAs，它们通过转录后改变巨噬细胞的激活。许多研究强调了 microRNAs 在肥胖应激下白色脂肪组织中 ATMs 的免疫功能和作为炎症调节因子的潜力的重要性。这篇综述总结了 microRNAs 在肥胖应激下白色脂肪组织中 ATMs 调控网络的最新知识。
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