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Sotorasib: a KRAS inhibitor for non-small cell lung cancer.

作者信息

Ganguly Arghya, Yoo Euna

机构信息

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

出版信息

Trends Pharmacol Sci. 2022 Jun;43(6):536-537. doi: 10.1016/j.tips.2022.03.011. Epub 2022 Apr 21.

Abstract
摘要

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本文引用的文献

1
Sotorasib: First Approval.
Drugs. 2021 Sep;81(13):1573-1579. doi: 10.1007/s40265-021-01574-2.
2
Sotorasib for Lung Cancers with p.G12C Mutation.
N Engl J Med. 2021 Jun 24;384(25):2371-2381. doi: 10.1056/NEJMoa2103695. Epub 2021 Jun 4.
3
KRAS Inhibition with Sotorasib in Advanced Solid Tumors.
N Engl J Med. 2020 Sep 24;383(13):1207-1217. doi: 10.1056/NEJMoa1917239. Epub 2020 Sep 20.
4
Discovery of a Covalent Inhibitor of KRAS (AMG 510) for the Treatment of Solid Tumors.
J Med Chem. 2020 Jan 9;63(1):52-65. doi: 10.1021/acs.jmedchem.9b01180. Epub 2019 Dec 24.
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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature. 2019 Nov;575(7781):217-223. doi: 10.1038/s41586-019-1694-1. Epub 2019 Oct 30.
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AMG 510 First to Inhibit "Undruggable" KRAS.
Cancer Discov. 2019 Aug;9(8):988-989. doi: 10.1158/2159-8290.CD-NB2019-073. Epub 2019 Jun 12.
7
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Nature. 2013 Nov 28;503(7477):548-51. doi: 10.1038/nature12796. Epub 2013 Nov 20.

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