医护人员混合队列中乙肝表面抗原（抗-HBs）的疫苗接种后抗体滴度。
Post vaccination antibody titres of hepatitis B surface antigen (anti-HBs) in a mixed cohort of health care workers.
作者信息
Lall Mahima, Sen Sourav, Patrikar Seema, Karade Santosh, Gupta R M
机构信息
Associate Professor, Department of Microbiology, Armed Forces Medical College, Pune, India.
Professor & Head, Department of Microbiology, Armed Forces Medical College, Pune, India.
出版信息
Med J Armed Forces India. 2022 Apr;78(2):198-203. doi: 10.1016/j.mjafi.2020.11.023. Epub 2021 Feb 27.
BACKGROUND
Hepatitis B (HepB) is an important vaccine preventable infection among healthcare workers (HCWs). Vaccination against Hep B virus, remains the foremost preventive approach. This study aims to measure the antibody titres to Hep B surface antigen (anti-HBs) in a mixed cohort of HCWs. It also aims to study the association between time since vaccination and the anti-HBs titres thus evaluating the duration of seroprotection.
METHODS
A total of 200 HCWs, including nursing students (n = 112), nursing staff (n = 49), laboratory technicians (n = 30) and doctors (n = 9) who had received all three doses of the Hep B vaccine and met the inclusion criteria of having taken all three doses of vaccine were included in this study. Anti-HBs titres were estimated by bioMérieux mini VIDAS® automated immunoassay based on the principle of enzyme-linked fluorescence assay.
RESULTS
Two hundred subjects aged 19 to 52 years were included in the study; mean age was 27.29 ± 0.568 years. Duration since vaccination in the study cohort was ≤ 5 years in 149 (74.5.0%), 6-10 years in 20 (10.0%) and >10 years in 31 (15.5%) subjects. Postvaccination antibody titres were > 100 mIU/ml in 85.0%, 10-100 mIU/ml in 11.0% and ≤ 10 mIU/ml in 3.5%. There was a decline noted in antibody titres as duration after vaccination increased. Increasing age was associated with falling protective titres.
CONCLUSION
The study revealed that majority of the HCWs had adequate anti-HBs titres and were protected after vaccination.
背景
乙型肝炎（乙肝）是医护人员中一种重要的可通过疫苗预防的感染性疾病。接种乙肝病毒疫苗仍然是首要的预防方法。本研究旨在测量一组混合的医护人员中乙肝表面抗原抗体（抗-HBs）滴度。它还旨在研究接种疫苗后的时间与抗-HBs滴度之间的关联，从而评估血清保护的持续时间。
方法
共有200名医护人员纳入本研究，包括护理专业学生（n = 112）、护理人员（n = 49）、实验室技术人员（n = 30）和医生（n = 9），他们均已接种完三剂乙肝疫苗且符合接种全部三剂疫苗的纳入标准。抗-HBs滴度通过生物梅里埃mini VIDAS®自动免疫分析测定，其基于酶联荧光分析原理。
结果
200名年龄在19至52岁的受试者纳入研究；平均年龄为27.29 ± 0.568岁。研究队列中接种疫苗后的时间≤5年的有149人（74.5%），6至10年的有20人（10.0%），超过10年的有31人（15.5%）。接种疫苗后的抗体滴度>100 mIU/ml的占85.0%，10至100 mIU/ml的占11.0%，≤10 mIU/ml的占3.5%。随着接种疫苗后时间的增加，抗体滴度呈下降趋势。年龄增加与保护性滴度下降相关。
结论
该研究表明，大多数医护人员具有足够的抗-HBs滴度，接种疫苗后受到了保护。
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