裂殖子表面被膜前体蛋白可使夜猴完全抵御恶性疟原虫疟疾。

Siddiqui W A, Tam L Q, Kramer K J, Hui G S, Case S E, Yamaga K M, Chang S P, Chan E B, Kan S C

Proc Natl Acad Sci U S A. 1987 May;84(9):3014-8. doi: 10.1073/pnas.84.9.3014.

Groups of Aotus (owl) monkeys were immunized with either the Plasmodium falciparum merozoite surface-coat precursor protein and its processing fragments or a complex of high molecular mass rhoptry proteins and challenged with a lethal infection of the homologous P. falciparum Uganda Palo Alto (FUP) strain. No patent parasitemia could be detected on thick blood films of monkeys immunized with the merozoite surface antigens; however, only one of three monkeys immunized with the rhoptry proteins was partially protected, while two required drug therapy. The experiment clearly demonstrates that the merozoite surface-coat precursor protein can completely protect Aotus monkeys against a lethal infection of the human malaria parasite.

将绢毛猴（夜猴）分组，分别用恶性疟原虫裂殖子表面被膜前体蛋白及其加工片段或高分子量棒状体蛋白复合物进行免疫，然后用同源的恶性疟原虫乌干达帕洛阿尔托（FUP）株进行致死性感染攻击。在用裂殖子表面抗原免疫的猴子的厚血膜上未检测到明显的寄生虫血症；然而，在用棒状体蛋白免疫的三只猴子中，只有一只受到部分保护，而另外两只需要药物治疗。该实验清楚地表明，裂殖子表面被膜前体蛋白可以完全保护绢毛猴免受人类疟原虫的致死性感染。